Evidence map›Paper›PMID 42909625›Full record

ArticleApplied microbiology and biotechnology2026

Reduced efficacy of food-chain biocides and preservatives against ciprofloxacin-resistant Salmonella Typhimurium.

Raúl Campillo, Ivo García-Penas, Celia Pardos, Patricia Gimeno, Daniel Berdejo, Rafael Pagán, Diego García-Gonzalo

Abstract read
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In one paragraph

Article in Applied microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Raúl CampilloDepartamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Instituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), C/Miguel Servet 177, 50013, Zaragoza, Spain.
Ivo García-PenasDepartamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Instituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), C/Miguel Servet 177, 50013, Zaragoza, Spain.
Celia PardosDepartamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Instituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), C/Miguel Servet 177, 50013, Zaragoza, Spain.
Patricia GimenoDepartamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Instituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), C/Miguel Servet 177, 50013, Zaragoza, Spain.
Daniel BerdejoDepartamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Instituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), C/Miguel Servet 177, 50013, Zaragoza, Spain.
Rafael PagánDepartamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Instituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), C/Miguel Servet 177, 50013, Zaragoza, Spain.
Diego García-GonzaloDepartamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Instituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), C/Miguel Servet 177, 50013, Zaragoza, Spain. Diego.Garcia@unizar.es.ORCID https://orcid.org/0000-0002-7629-8101

Funding

Agencia Estatal de Investigación PID2021-123404NB-I00Agencia Estatal de Investigación PID2024-156601NA-I00Departamento de Educación, Cultura y Deporte, Gobierno de Aragón Predoc contractGobierno de Aragón Grupo AESA A06_23RMinisterio de Ciencia, Innovación y Universidades FPU24/03863
6 · The paper itself

Abstract

A wide range of microbial prevention and control strategies are applied along the agri-food chain to combat the transmission of foodborne pathogens to the final consumer. These strategies range from traditional thermal treatments to emerging technologies as well as the use of food chain biocides to reduce microbial loads on raw materials and food contact surfaces, and preservatives for the preservation of feed and food products. However, bacteria have demonstrated a remarkable ability to adapt to and overcome these food-related stresses, often resulting in reduced susceptibility to other seemingly unrelated agents through cross-protection mechanisms. In this study, we aimed to evaluate the outcomes of ciprofloxacin (CIP) antimicrobial resistance (AMR) in Salmonella Typhimurium and its potential relationship with cross-protection to food-chain biocides and preservatives, as well as the ability of the resistant variants (RVs) to retain their virulence. The CIP-RVs showed heterogeneous and compound-dependent responses to the tested food-chain antimicrobial compounds. All five RVs displayed increased tolerance to at least one compound, but cross-protection was not uniform across strains or treatments. Notably, SeT

Indexed as

Anti-Bacterial AgentsCiprofloxacinDisinfectantsDrug Resistance, BacterialFood PreservativesSalmonella typhimuriumAnimalsFood MicrobiologyFood PreservationMicrobial Sensitivity TestsVirulenceAnti-Bacterial AgentsCiprofloxacinDisinfectantsFood PreservativesAMRDisinfectantsFood preservationGenetic changesPreservativesVirulence

Identifiers

PMID42909625

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.