ArticleAnalytical and bioanalytical chemistry2026
APV-Sankey: a k-mer persistence visualization tool for HT-SELEX data analysis to identify aptamer candidates.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
APV-Sankey is a novel visualization and analysis tool for High-Throughput Systematic Evolution of Ligands by Exponential Enrichment (HT-SELEX) data. By tracking k-mer persistence and concatenation across SELEX rounds via Sankey diagrams, APV-Sankey provides a complementary framework for identifying aptamer candidates, assessing SELEX progression, and facilitating the interpretation of HT-SELEX data. We demonstrate that k-mer persistence analysis captures biologically relevant patterns in SELEX evolution, complementing existing approaches based on sequence abundance. We benchmark APV-Sankey against standard metrics including final-round abundance, fold enrichment, and k-mer frequency, showing that persistence provides an orthogonal ranking dimension (Spearman ρ = - 0.192 with abundance) with 90% of top-200 persistent k-mers unique to the persistence ranking. APV-Sankey generates structured, round-annotated k-mer datasets suitable for downstream deep learning applications in aptamer binding prediction, positioning it as a data analysis platform for in silico aptamer research.
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