Evidence map›Paper›PMID 42909577›Full record

ArticleInfectious diseases and therapy2026

Rise of Lower Respiratory Tract Infections Other than Respiratory Syncytial Virus in the Emergency Room: Results from the Season (2024/25) of the RISE Study.

Maria Adams, Vivien Greese, Anissa Paschereit, Tamina Schenck, Julia Kristin Singer, Johannes Paul Paulick, Rafael Paolo Pricoco, Hermann Girschick, Eva Jenz, Martina Rabe and 4 more

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Article in Infectious diseases and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Maria AdamsSana Klinikum Lichtenberg Berlin, Clinic for Child and Adolescent Medicine, Academic Teaching Hospital Charité-Universitätsmedizin Berlin, Fanningerstr. 32, 10365, Berlin, Germany.
Vivien GreeseSana Klinikum Lichtenberg Berlin, Clinic for Child and Adolescent Medicine, Academic Teaching Hospital Charité-Universitätsmedizin Berlin, Fanningerstr. 32, 10365, Berlin, Germany.
Anissa PaschereitSana Klinikum Lichtenberg Berlin, Clinic for Child and Adolescent Medicine, Academic Teaching Hospital Charité-Universitätsmedizin Berlin, Fanningerstr. 32, 10365, Berlin, Germany.
Tamina SchenckSana Klinikum Lichtenberg Berlin, Clinic for Child and Adolescent Medicine, Academic Teaching Hospital Charité-Universitätsmedizin Berlin, Fanningerstr. 32, 10365, Berlin, Germany.
Julia Kristin SingerChildren's Hospital, Vivantes Klinikum Friedrichshain, Berlin, Germany.
Johannes Paul PaulickChildren's Hospital, Vivantes Klinikum Friedrichshain, Berlin, Germany.
Rafael Paolo PricocoChildren's Hospital, Vivantes Klinikum Friedrichshain, Berlin, Germany.
Hermann GirschickChildren's Hospital, Vivantes Klinikum Friedrichshain, Berlin, Germany.
Eva JenzZEG - Berlin Center for Epidemiology and Health Research, Berlin, Germany.
Martina RabeZEG - Berlin Center for Epidemiology and Health Research, Berlin, Germany.
Marta Gil-PawlakChildren's Hospital, Vivantes Klinikum Friedrichshain, Berlin, Germany.
Christine GinocchioStat-Dx Life (QIAGEN), Barcelona, Spain.
Christine HagemannSANOFI Vaccines, Berlin, Germany.
Tobias TenenbaumSana Klinikum Lichtenberg Berlin, Clinic for Child and Adolescent Medicine, Academic Teaching Hospital Charité-Universitätsmedizin Berlin, Fanningerstr. 32, 10365, Berlin, Germany. tobias.tenenbaum@sana-kl.de.ORCID http://orcid.org/0000-0002-7215-8398

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAcute respiratory infections (ARI) are a major cause of pediatric emergency department (ED) visits and hospitalizations. Although respiratory syncytial virus (RSV), influenza, and rhinovirus (RV) are common etiological agents, pathogen-specific data from pediatric emergency settings remain limited.

methodsThis prospective surveillance study quantified ARI-related ED visits, described pathogen-specific epidemiology, and assessed attendance and hospitalization rates as well as the distribution of lower versus upper respiratory tract infections (LRTI/URTI) in children younger than 60 months in two pediatric EDs in Berlin between November 1, 2024 and May 31, 2025. Respiratory pathogens were identified using nasopharyngeal swab samples tested by multiplex real-time RT-PCR (QIAstat-Dx

resultsWithin the study period 4042 ARI-related ED visits occurred. A total of 310 children were enrolled in our study (median age 18 months); 115 (37.1%) had LRTI and 195 (62.9%) URTI. At least one respiratory pathogen was detected in 271 children (87.4%). The attendance rate for RSV was 24.4% (66 cases), for FLU 25.8% (70 cases), and for RV 29.5% (80 cases). Overall, 93 children (30.0%) were hospitalized, including 65 with LRTI and 28 with URTI. Hospitalization rates were highest for RSV infections (26/65, 40.0%) and RV infections (28/65, 43.1%), and lower for FLU infections (13/69, 18.8%). Hospitalization due to LRTI predominated among children with RSV (24/26, 92.3%) and RV infections (20/28, 71.4%), whereas FLU infections were less frequently observed (7/13, 53.9%). Furthermore, younger age, a history of pneumonia, a history of bronchiolitis, and the absence of breastfeeding were associated with hospitalization.

conclusionsIn contrast to the previous season, in which RSV was associated with the highest attendance and hospitalization rate, we observed a high burden of RV infections in the 2024/2025 season. These findings may impact surveillance strategies, clinical management, and future public health strategies.

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Emergency roomEpidemiologyHospitalizationRespiratory tract infection

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.