Reconstructing the Tumor Mechanical Microenvironment in Organoids: From Mechanical Cues to Biomimetic Modeling and Therapeutic Insights.

Shuying Yan, Jing Zhu, Joaquim M Oliveira, Rui L Reis, Leping Yan, Lin Xiao

Abstract readReview

In one paragraph

Review in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuying YanSchool of Biomedical Engineering, Shenzhen Campus, Sun Yat-Sen University, Shenzhen, China.

Jing ZhuSchool of Biomedical Engineering, Shenzhen Campus, Sun Yat-Sen University, Shenzhen, China.

Joaquim M Oliveira3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark - Parque de Ciência e Tecnologia, Rua Ave 1, Edifício 1 (Sede), 4805-0 17, Barco, Guimarães, Portugal.

Rui L Reis3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark - Parque de Ciência e Tecnologia, Rua Ave 1, Edifício 1 (Sede), 4805-0 17, Barco, Guimarães, Portugal.

Leping YanDepartment of Scientific Research Center, Department of Critical Care Medicine, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.

Lin XiaoSchool of Biomedical Engineering, Shenzhen Campus, Sun Yat-Sen University, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tumor mechanical microenvironment (TMME) is a critical regulator of cancer initiation, progression, metastasis, and therapeutic response. Beyond biochemical signaling, physical cues such as matrix stiffness, solid stress, interstitial fluid flow, and extracellular matrix (ECM) architecture regulate tumor-cell behavior, stromal remodeling, abnormal vascular proliferation and leakage, immune interactions, and drug resistance. However, conventional

Indexed as

BiomimeticsNeoplasmsOrganoidsTumor MicroenvironmentAnimalsBioprintingCoculture TechniquesExtracellular MatrixHumansModels, Biologicalengineered extracellular matrixmechanobiologytumor mechanical microenvironmenttumor organoids

Identifiers

PMID42909412

DOI10.7150/ijms.138880

PMCPMC13685040

What OpenQuestion holds

Textmetadata

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.