Effects of Resveratrol on Anxiety-Like Behavior, Neuronal Damage, and Apoptotic Signaling in Female Rats Exposed to Methylparaben.

Entesar AlShammari, Promy Virk, Dalal Alkhelb, Fawaz Alasmari, Wasayf Alotibi, Nouf Alsultan, Gadah Albasher

Abstract read

In one paragraph

Article in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Entesar AlShammariDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.

Promy VirkDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.

Dalal AlkhelbDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Fawaz AlasmariDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Wasayf AlotibiDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.

Nouf AlsultanFaculty of Medicine and Health Sciences, Medical School, University of Nottingham, Nottingham NG7 2QL, UK.

Gadah AlbasherDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methylparaben (MEP), a widespread preservative, raises neurotoxicity concerns through oxidative stress and inflammation. Resveratrol (RES) is a natural polyphenol with antioxidant and anti-inflammatory properties. This study investigated whether RES protects against MEP-induced neurotoxicity in female rats. Female Wistar rats were divided into five groups (n=10/group): control, vehicle (5% DMSO), MEP alone (200 mg/kg, s.c., 15 days), RES alone (20 mg/kg, i.p., 15 days), and MEP+RES co-treatment. We evaluated anxiety-like behavior (elevated plus maze), brain histopathology (cortex/hippocampus), oxidative stress markers (GSH, SOD), stress-related gene expression (

Indexed as

AnxietyNeurotoxicity SyndromesParabensResveratrolAnimalsAntioxidantsApoptosisBehavior, AnimalDisease Models, AnimalFemaleHippocampusHumansNeuronsNeuroprotective AgentsOxidative StressRatsAntioxidantsmethylparabenNeuroprotective AgentsParabensResveratrolanxietymethylparabenneurobiologyneuroinflammationresveratrol

Identifiers

PMID42909400

DOI10.7150/ijms.138134

PMCPMC13685036

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.