Evidence map›Paper›PMID 42909306›Full record

ReviewFrontiers in immunology2026

Autophagy, endolysosomes and extracellular space in autoimmune and innate immune defects.

Juliane Schuler, Lea Tollmann, Robert Walter Körner, Birk Möller, Emil Schober, Charlotte Schöner, Maaike Kusters, Ming Lim, Tim Niehues, Heinz Jungbluth and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Juliane Schuler *Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Lea Tollmann *Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Robert Walter KörnerDepartment of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Birk MöllerDepartment of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Emil SchoberDepartment of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Charlotte SchönerDepartment of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Maaike KustersDepartment of Immunology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.
Ming LimChildren's Neuroscience, Evelina London Children's Hospital at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Tim NiehuesHelios Klinikum Krefeld, HMU Health Medical University Campus Düsseldorf/Krefeld, Düsseldorf, Germany.
Heinz Jungbluth *Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Hormos S Dafsari *Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy is increasingly recognized as a central immunological process whose roles extend far beyond intracellular recycling. By coordinating lysosomal degradation, organelle quality control, selective antimicrobial clearance, and inflammatory signal termination, autophagy acts as a decisive checkpoint at the crossroads between protective innate immunity and pathological immune persistence. Xenophagy, the selective autophagic elimination of intracellular pathogens, is a particularly important process at the interface between host defense, endosomal trafficking and immune resolution. Distinct monogenic disorders affecting

Indexed as

Autoimmune DiseasesAutoimmunityAutophagyEndosomesExtracellular SpaceImmunity, InnateLysosomesAnimalsExtracellular TrapsHumansautoimmunityautophagyendosomesinnate immunityneutrophil extracellular traps

Identifiers

PMID42909306
PMCPMC13684790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.