Evidence map›Paper›PMID 42909294›Full record

ReviewTheranostics2026

Hybrid exosome-liposome nanovesicles as delivery platforms for therapeutic applications: merging the best of both worlds.

Jian Yu, Lujiao Yu, Fei Ren, Kai Cui, Gongping Sun, Hong Pan

Abstract readReview
In one paragraph

Review in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jian YuDepartment of Neurosurgery, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshandong Road, Shenyang, 110032, China.
Lujiao YuDepartment of Geriatrics, The First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China.
Fei RenDepartment of Geriatrics, The First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China.
Kai CuiDepartment of Orthopaedics, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshandong Road, Shenyang, 110032, China.
Gongping SunDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshandong Road, Shenyang, 110032, China.
Hong PanDepartment of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshandong Road, Shenyang, 110032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are increasingly employed to treat various diseases because of their remarkable ability to enhance the stability of encapsulated cargoes. This capability is attributed to their outstanding homologous targeting, desirable biocompatibility, and low immunogenicity, thereby contributing to improved therapeutic outcomes. Nevertheless, exosomes are constrained by some limitations, including poor loading capacity, inherent heterogeneity, and challenges in large-scale production. Consequently, hybrid exosome-liposome (EL) systems, which can circumvent these limitations, are playing an increasingly crucial role in therapeutic applications. Herein, we introduce the two primary strategies for drug loading into exosomes -- passive loading and active loading. We further elaborate on the fabrication methods of hybrid ELs and their applications in drug delivery, highlighting the innate advantages of these state-of-the-art nanovesicles over conventional exosomes and liposomes. Major challenges and future perspectives of hybrid ELs in treating various diseases are also discussed.

Indexed as

Drug CarriersDrug Delivery SystemsExosomesLiposomesNanoparticlesAnimalsHumansDrug CarriersLiposomesdrug deliveryexosomeliposomemembrane fusionnanovesicle

Identifiers

PMID42909294
PMCPMC13684820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.