Evidence map›Paper›PMID 42909176›Full record

ReviewJID innovations : skin science from molecules to population health2026

Cutaneous endothelial cells and their roles in wound healing.

Haiming Li, Laura Sormani Le Bourhis, Seen-Ling Sim, Abbas Shafiee, Kiarash Khosrotehrani

Abstract readReview
In one paragraph

Review in JID innovations : skin science from molecules to population health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haiming LiFrazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Laura Sormani Le BourhisFrazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Seen-Ling SimFrazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Abbas ShafieeFrazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Kiarash KhosrotehraniFrazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial cells (ECs) form the inner monolayer of blood and lymphatic vessels play an essential role in skin homeostasis and wound healing. Upon injury, ECs rapidly engage in the healing response. ECs promote wound healing by forming new blood vessels through angiogenesis to supply oxygen, nutrients, and signals needed for tissue repair. Diseases like diabetes can cause endothelial dysfunction, leading to defective neovascularization and delayed wound closure. This review focuses on the intrinsic roles of ECs in each phase of skin wound healing, extending beyond their roles in vascularization, and discusses therapeutic strategies that target those functions to improve healing outcomes. Recognizing ECs as dynamic regulators of wound repair, rather than merely structural components of blood vessels, could open new therapeutic avenues for regenerative skin therapies.

Indexed as

AngiogenesisInflammationRegenerative medicineScarringVascular–immune crosstalk

Identifiers

PMID42909176
PMCPMC13683847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.