Evidence map›Paper›PMID 42909098›Full record

ArticleiScience2026

Stathmin 1 regulates mitophagy and non-proliferative cellular function in hematopoietic stem and progenitor cells.

Luana Chiquetto, Meg Schuetz, Qian Dong, Mia Warmka, Liana Valin, Ashley Jones, Patrick Hunt, Copper Petermeier, Jie Wang, Nate Roundy and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Luana ChiquettoDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Meg SchuetzDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Qian DongDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mia WarmkaDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Liana ValinDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ashley JonesDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Patrick HuntDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Copper PetermeierDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jie WangDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Nate RoundyDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Zev J GreenbergDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Wei YangDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Christine R ZhangDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Grant A ChallenDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cliff J LukeDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Robert A J SignerDepartment of Medicine, Sanford Stem Cell Institute, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Wandy L BeattyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Stephen SykesDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Weikai LiDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.
David J KastDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Laura G SchuettpelzDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stathmin 1 is a cytoplasmic phosphoprotein that regulates microtubule dynamics. Stathmin 1 expression is a feature of proliferating cells, and it is overexpressed in many cancers, including leukemias. In contrast to its roles in proliferating cells, considerably less is known of stathmin 1 in quiescent cells. Importantly, stathmin 1 is highly expressed in hematopoietic stem and progenitor cells (HSPCs), and herein we found that stathmin 1 loss is associated with altered microtubule architecture and markedly impaired HSPC function. Transcriptomic studies suggested metabolic differences in

Indexed as

autophagyhematopoietic stem cellsmetabolismmicrotubulesmitophagystathmin

Identifiers

PMID42909098
PMCPMC13683780

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.