Evidence map›Paper›PMID 42909058›Full record

ArticleFrontiers in psychology2026

Personality traits and biological aging: the mediating role of coping behavior.

Shirui Peng, Zixuan Li, Tao Huang, Hailun Liang

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Article in Frontiers in psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shirui PengSchool of Public Administration and Policy, Renmin University of China, Beijing, China.
Zixuan LiBeijing Center for Disease Prevention and Control, Beijing, China.
Tao HuangDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.
Hailun LiangSchool of Population and Health, Renmin University of China, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Evidence linking Big Five personality traits to clinical biomarker-based PhenoAge acceleration remains limited, and the behavioral pathways underlying these associations are not well understood. Objective: This study examined the associations between Big Five personality traits and PhenoAge acceleration (PhenoAA), tested health-related coping behavior as a statistical mediator, and explored differences across genetic risk strata. Methods: We conducted a cross-sectional analysis of 119,250 European-ancestry participants from the UK Biobank. PhenoAA was derived from clinical biomarker-based PhenoAge after adjusting for chronological age. Multivariable linear regression, mediation analysis, inverse-probability-weighted sensitivity analysis, and exploratory analyses stratified by a genetic risk score (GRS) based on 29 single-nucleotide polymorphisms were performed. Results: Neuroticism was positively associated with PhenoAA ( Conclusion: Big Five personality traits were associated with PhenoAA, and coping behavior partly accounted for several of these associations. These findings support a biopsychosocial view of biological aging, but they should be interpreted as associations rather than causal relationships.

Indexed as

Biological agingCoping behaviorGenetic riskPersonality traitsPhenoAge acceleration

Identifiers

PMID42909058
PMCPMC13683731

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.