Evidence map›Paper›PMID 42909053›Full record

ArticleiScience2026

Gammaherpesvirus infection of myeloid cells reveals divergent outcomes regulated by host and viral factors.

Gabrielle Vragel, Kyra S Noell, Ashley Tseng, Rachael E Kostelecky, Elizabeth A Alexander, Shirli Cohen, Catalina Galvan, Manaal Dalwadi, Brittany D Gomez, Eva M Medina and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gabrielle VragelDepartment of Immunology and Microbiology, University of Colorado Denver | Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.
Kyra S NoellDepartment of Medicine, University of Colorado Denver | Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.
Ashley TsengHarvard Graduate School, Cambridge, MA 02138, USA.
Rachael E KosteleckyDepartment of Immunology and Microbiology, University of Colorado Denver | Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.
Elizabeth A AlexanderDepartment of Immunology and Microbiology, University of Colorado Denver | Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.
Shirli CohenDepartment of Immunology and Microbiology, University of Colorado Denver | Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.
Catalina GalvanMayo Clinic Graduate School, Rochester, MN 55905, USA.
Manaal DalwadiDepartment of Immunology and Microbiology, University of Colorado Denver | Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.
Brittany D GomezDepartment of Pediatrics, University of Colorado Denver | Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.
Eva M MedinaDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver | Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.
Darby G OldenburgGundersen Medical Foundation, Emplify Health System, La Crosse, WI 54601, USA.
Andrew GoodspeedUniversity of Colorado Cancer Center, University of Colorado Denver | Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.
Eric T ClambeyDepartment of Anesthesiology, University of Colorado Denver | Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.
Linda F van DykDepartment of Immunology and Microbiology, University of Colorado Denver | Anschutz Medical Campus, School of Medicine, Aurora, CO 80045, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gammaherpesviruses establish a lifelong infection, with the cellular outcome of infection intimately regulated by cell type. Myeloid cells are an early infection target characterized by diverse outcomes. To investigate this, we use murine gammaherpesvirus 68 to demonstrate that macrophages are readily infectable, resulting in three divergent infection outcomes dictated by viral and host factors. Infection

Indexed as

DNA tumor viruslatentlyticmacrophageMHV68murid herpesvirus 4murine gammaherpesvirus 68

Identifiers

PMID42909053
PMCPMC13683751

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.