ArticleFrontiers in sports and active living2026
Case Report: Metabolic adaptations to intensive aerobic training in Parkinson's disease: autonomic and physiopathological response.
Article in Frontiers in sports and active living, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Aerobic exercise is a key non-pharmacological intervention in Parkinson's disease (PD), yet the physiological mechanisms underlying its therapeutic effects remain incompletely understood. This case report aimed to investigate metabolic and cardiovascular adaptations to an intensive aerobic training programme in a person with PD, with particular focus on metabolic efficiency and insulin-like growth factor 1 (IGF-1) response. Methods: A 72-year-old man with idiopathic PD (Hoehn & Yahr stage II, ON medication) participated in a 4-week intensive treadmill training programme (20 sessions) within the METEX-PD protocol. Exercise was performed at a constant external workload (5.0-5.5 km·h⁻ Results: Progressive reductions in HR, Discussion: Intensive aerobic training induced favourable metabolic adaptations in this individual with PD, as evidenced by improved aerobic efficiency and increased circulating IGF-1 levels. These adaptations occurred despite potential autonomic dysfunction affecting cardiovascular responses. The findings support the use of direct metabolic measurements to better characterise training adaptations and optimise individualised aerobic exercise prescription in people with PD. Further studies are warranted to confirm these observations in larger cohorts.
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