ArticleFrontiers in pharmacology2026
A mixture of pomegranate peels and propolis extracts reduces inflammation associated with rheumatoid arthritis
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Rheumatoid arthritis (RA) is a chronic condition characterized by the infiltration of immune and inflammatory cells into the synovial membranes, which often leads to severe damage to cartilage and bone. In spite of their efficacy, drug-based therapies produce severe side effects. Therefore, there remains an unmet need for non-pharmacological treatments with a low toxicity profile and limited costs. Propolis has been used since ancient times for the treatment of wounds, ulcers, infections, eczemas, myalgia, and rheumatism. Similarly, the traditional use of all parts of pomegranate ( Purpose: This study aimed at the development of preparations containing bioactive compounds derived from propolis and pomegranate peels, inspired by traditional recipes used in rural areas of southern Italy, to validate their efficacy in counteracting the inflammation associated with RA. Materials and methods: A preliminary screening led to the selection of the most promising preparation, composed by propolis and pomegranate peel extracts in a ratio 1:2 (Pp1:2). It underwent a complete chemical characterization by both qualitative and quantitative LC-MS analyses and was tested on a collagen-induced arthritis (CIA) mouse model. Results:
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