Evidence map›Paper›PMID 42908875›Full record

ArticleBone reports2026

Irisin fails to rescue bone loss in a rat model of chronic kidney disease - mineral bone disorder (CKD-MBD) but interacts with parathyroid hormone (PTH)

Hannah E Wilson, Neal X Chen, Kalisha D O'Neill, Corinne E Metzger, Shruthi Srinivasan, Daniel J Stephen, Karis Blacklock, Emily K Matter, Lynda F Bonewald, Matthew R Allen and 1 more

Abstract read
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In one paragraph

Article in Bone reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hannah E WilsonDepartment of Anatomy, Cell Biology, and Physiology, USA.
Neal X ChenDivision of Nephrology & Hypertension, Department of Medicine, USA.
Kalisha D O'NeillDivision of Nephrology & Hypertension, Department of Medicine, USA.
Corinne E MetzgerDepartment of Anatomy, Cell Biology, and Physiology, USA.
Shruthi SrinivasanDivision of Nephrology & Hypertension, Department of Medicine, USA.
Daniel J StephenDepartment of Anatomy, Cell Biology, and Physiology, USA.
Karis BlacklockDepartment of Anatomy, Cell Biology, and Physiology, USA.
Emily K MatterDepartment of Anatomy, Cell Biology, and Physiology, USA.
Lynda F BonewaldIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Matthew R AllenDepartment of Anatomy, Cell Biology, and Physiology, USA.
Sharon M MoeDivision of Nephrology & Hypertension, Department of Medicine, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chronic kidney disease progression leads to bone loss and increased fracture and mortality risk. The myokine irisin, produced by muscle during exercise, has been shown to exert protective effects on bone in healthy animals and exhibits a potential interaction with PTH Methods: Early and mature IDG-SW3 osteocytes were treated with recombinant irisin, PTH, or both. Mineralization and osteocyte cell markers were assessed. In a similar 2 × 2 design, male Cy/+ Results: Conclusions: Irisin did not meaningfully ameliorate bone loss in an animal model of CKD-MBD but did interact with PTH by downregulating its receptor

Indexed as

Chronic kidney diseaseIrisinMyokineOsteocytesParathyroid hormone

Identifiers

PMID42908875
PMCPMC13683239

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.