Evidence map›Paper›PMID 42908728›Full record

ArticleAddictive behaviors reports2026

A pilot randomized controlled trial of an integrative psychotherapy incorporating an attachment-based approach for adolescents with cannabis use disorder (TIMCA).

Bou Nassif Yara, Richter Joachim, Kheirallah Lana, Farquhar Farrell, Gonnod Alix, Cros Carolina, Benyamina Amine, Varescon Isabelle, Rahioui Hassan

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Article in Addictive behaviors reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Bou Nassif YaraService des troubles du neuro-développement chez l'adulte, Groupe Hospitalier Universitaire Paris psychiatrie et neurosciences, Paris, France.
Richter JoachimService des troubles du neuro-développement chez l'adulte, Groupe Hospitalier Universitaire Paris psychiatrie et neurosciences, Paris, France.
Kheirallah LanaService des troubles du neuro-développement chez l'adulte, Groupe Hospitalier Universitaire Paris psychiatrie et neurosciences, Paris, France.
Farquhar FarrellService des troubles du neuro-développement chez l'adulte, Groupe Hospitalier Universitaire Paris psychiatrie et neurosciences, Paris, France.
Gonnod AlixService de psychiatrie et addictologie, Assistance Publique-Hôpitaux de Paris, Paris, France.
Cros CarolinaService de psychiatrie et addictologie, Assistance Publique-Hôpitaux de Paris, Paris, France.
Benyamina AmineService de psychiatrie et addictologie, Assistance Publique-Hôpitaux de Paris, Paris, France.
Varescon IsabelleLaboratoire de psychopathologie et processus de santé, Université Paris Cité, Boulogne-Billancourt, France.
Rahioui HassanService des troubles du neuro-développement chez l'adulte, Groupe Hospitalier Universitaire Paris psychiatrie et neurosciences, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cannabis is the most used illicit substance among adolescents. Regular cannabis use is linked to cognitive and psychosocial difficulties. As no pharmacological treatment has proven effective, psychological interventions, including motivational interviewing (MI), cognitive-behavioral therapy (CBT), and family-based approaches, remain central. However, adolescent-specific evidence remains limited. TIMCA was developed as a ten-session integrative psychotherapy combining MI, CBT, and integrated attachment therapy. While family therapy may not be indicated for all adolescents, parental involvement remains important for the adolescent-parent relationship. TIMCA therefore combines individual and parent-adolescent sessions to address cannabis use alongside attachment-related and emotion-regulation processes. Objectives: This pilot randomized controlled trial evaluated the feasibility and acceptability of TIMCA and explored changes over time in cannabis use and relational, emotional, anxiety/depressive, and treatment-adherence outcomes compared with treatment as usual (TAU). Methods: Thirty-nine adolescents with cannabis use disorder were randomly assigned to TIMCA ( Results: TIMCA was feasible and acceptable, with high treatment adherence. Exploratory analyses showed significant within-group changes, including reductions in cannabis use, emotion dysregulation, and depressive symptoms, along with improved attachment security. In TAU, within-group changes did not reach statistical significance, and no significant between-group differences were detected. Conclusion: TIMCA appears feasible and acceptable, supporting further evaluation in adequately powered trials with longer follow-up.

Indexed as

Adolescentscannabis use disorderCognitive-behavioral therapyIntegrated, attachment therapyIntegrative psychotherapyMotivational interviewing

Identifiers

PMID42908728
PMCPMC13683235

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.