ArticleAmerican journal of cancer research2026
Perioperative and oncological outcomes of single-port versus two-port thoracoscopic lobectomy for non-small cell lung cancer: a propensity score-matched retrospective study.
Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Although single-port video-assisted thoracoscopic surgery (VATS) lobectomy is increasingly adopted for non-small cell lung cancer (NSCLC), evidence comparing its long-term oncological efficacy with that of the two-port approach remains scarce. This propensity score-matched study evaluated perioperative outcomes, postoperative recovery, and 3-year survival following single-port versus two-port thoracoscopic lobectomy in patients with NSCLC. We retrospectively analyzed 167 consecutive patients (single-port, n = 82; two-port, n = 85); propensity score matching (1:1, caliper = 0.2) yielded 72 matched pairs. Perioperative outcomes, postoperative pain (VAS), inflammatory markers (CRP, PCT, IL-1β), pulmonary function, 30-day complications, 3-year overall survival (OS), disease-free survival (DFS), and multivariable Cox regression were compared. Following matching, the single-port group demonstrated significantly longer operative time (187.3 ± 56.4 vs. 142.2 ± 49.4 minutes; P<0.001) but reduced blood loss (96.5 ± 42.0 vs. 121.7 ± 48.1 mL; P<0.001) 24-hour chest drainage volume (632.3 ± 447.3 vs. 945.5 ± 501.3 mL; P<0.001), and incision length (3.57 ± 1.37 vs. 4.94 ± 1.52 cm; P<0.001). Lymph node yield did not differ significantly (17.3 ± 4.1 vs. 16.1 ± 3.6; P = 0.058). Postoperative VAS scores were significantly lower in the single-port group on days 3, 5, and 7 (all P<0.001), with attenuated inflammatory responses (lower CRP, PCT, and IL-1β; all P<0.001) and better pulmonary function recovery (higher PaO
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