ArticleFrontiers in medicine2026
Multimodal MRI of choroid plexus volume, DTI-ALPS, and white matter microstructure in type 2 diabetes mellitus.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate differences in choroid plexus volume (CPV), diffusion tensor image analysis along the perivascular space (DTI-ALPS) indices, peak width of skeletonized mean diffusivity (PSMD), and Mini-Mental State Examination (MMSE) scores between patients with type 2 diabetes mellitus (T2DM) and healthy controls, and to explore pairwise associations among diabetes duration, PSMD, normalized total CPV, total DTI-ALPS, and MMSE within the T2DM group. Methods: This retrospective cross-sectional study included 31 patients with T2DM and 31 healthy controls (HCs). All participants underwent 3.0-T MRI and MMSE assessment. General linear models were used to compare normalized CPV, DTI-ALPS indices, PSMD, and MMSE scores between groups, adjusting for age, sex, body mass index, and years of education. Within the T2DM group, exploratory partial correlations were performed among diabetes duration, PSMD, normalized total CPV, total DTI-ALPS, and MMSE, controlling for the same covariates. The resulting 10 pairwise associations were corrected together using the Benjamini-Hochberg false discovery rate (FDR) procedure. Results: Compared with HCs, patients with T2DM showed greater normalized total and bilateral CPV, lower total DTI-ALPS, higher PSMD, and lower MMSE scores (all Conclusion: Patients with T2DM showed differences in CPV, DTI-ALPS, PSMD, and MMSE scores. Longer diabetes duration was associated with higher PSMD after FDR correction, whereas the CPV-DTI-ALPS association did not survive multiple-comparison correction. These findings highlight the value of multimodal MRI for characterizing brain involvement in T2DM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.