ArticleFrontiers in cardiovascular medicine2026
Genetic-risk-informed integration of bulk and single-cell transcriptomes prioritizes
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Aortic dissection is characterized by vascular wall remodeling and inflammatory activation, but the cell-associated molecular programs linking transcriptional alterations to genetic susceptibility remain incompletely defined. This study aimed to identify reproducible monocyte-associated molecular candidates in aortic dissection. Methods: We integrated bulk transcriptomic discovery (GSE153434) with an exploratory secondary-cohort assessment (GSE52093), single-cell RNA sequencing (GSE189795), FinnGen genome-wide association study summary statistics, scPagwas, and cell-type-specific hdWGCNA. Results: Genetic risk-informed analysis highlighted myeloid populations, particularly monocytes and neutrophils. Integration of bulk differential expression, scPagwas correlations, and a disease-associated monocyte hdWGCNA module prioritized Conclusion: Integrative genetic and transcriptomic analyses prioritized
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.