SynthesisFrontiers in nephrology2026
Mapping the aging kidney: a bibliometric atlas of cellular senescence and future frontiers since the 20th century.
Synthesis in Frontiers in nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Kidney disease is a major global public health challenge. The pathological mechanisms linking chronic kidney disease (CKD) and age-related kidney function decline are complex. Cellular senescence and its senescence-associated secretory phenotype (SASP) act as key links between kidney aging and disease progression. Although publications in this field have surged, a systematic bibliometric analysis is needed to outline its knowledge framework, research hotspots, and future trends. This study aims to quantitatively analyze global publication trends, core contributors (countries, institutions, journals, and authors), and cooperation networks to map the dynamic evolution of this field. Methods: We conducted a comprehensive literature search across both the Web of Science Core Collection (WoSCC) and Scopus databases to retrieve original articles and reviews concerning cellular senescence and kidney aging published between 2000 and 2025. After merging the datasets and removing duplicates, a meticulous bibliometric analysis was executed using Excel 365, CiteSpace, VOSviewer, and Bibliometrix (an R package) to map the knowledge framework and cooperation networks. Results: This analysis included 2,191 relevant papers involving 16,545 researchers. The overall publication volume showed significant growth, reaching a peak in 2025. The United States leads the field with the most publications and the highest citation frequency. China ranks second in publications but fourth in citations, reflecting a gap in research quality. The collaboration network indicates that the United States is the core node, maintaining close ties with countries like China and Germany. The Conclusion: This study maps the evolutionary trends of research on cellular senescence and related kidney diseases, identifying current frontiers and providing data to support future research. The rise of concepts like machine learning, ferroptosis, and Mendelian randomization marks a deep shift in the research paradigm, offering new perspectives for future scientific exploration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.