Evidence map›Paper›PMID 42908589›Full record

ArticleFrontiers in cellular neuroscience2026

Caveolin-1 defines astrocyte mechanobiology in the glial lamina of the optic nerve head.

Anja K Hoffmann, Anna Dlugosch, Michelle C Geigenfeind, Amelie Seemann, Michael H Elliott, Rudolf Fuchshofer, Andrea E Dillinger

Abstract read
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In one paragraph

Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anja K HoffmannInstitute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany.
Anna DlugoschInstitute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany.
Michelle C GeigenfeindInstitute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany.
Amelie SeemannInstitute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany.
Michael H ElliottDepartment of Biochemistry & Physiology, The University of Oklahoma Health Campus, Oklahoma, OK, United States.
Rudolf Fuchshofer *Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany.
Andrea E Dillinger *Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The optic nerve head is the principal site of retinal ganglion cell axonal injury in primary open angle glaucoma, where astrocyte mechanobiology and extracellular matrix remodeling are thought to play critical roles in disease progression. Caveolae, which are mechanosensitive plasma membrane invaginations formed by Caveolin and Cavin proteins, are key regulators of cellular responses to mechanical stress, yet their involvement in optic nerve head pathophysiology has not been defined. Here, we characterize the presence, regulation, and mechanobiological relevance of Caveolin and Cavin proteins in murine optic nerve astrocytes

Indexed as

extracellular matrixglaucomaIOPmechanical loadoptic nerve

Identifiers

PMID42908589
PMCPMC13683092

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.