Evidence map›Paper›PMID 42908540›Full record

ArticleThe journal of allergy and clinical immunology. Global2026

Guidelines for the management of adult penicillin allergy in community and specialist settings in Australia and New Zealand: An AGREE II and Delphi-based approach.

Michaela Lucas, Jillian Kehoe, Samantha Stiles, Sandra M Salter, Jacqueline Loprete, Catherine J Hornung, Lara Martin, Syed B Ali, Rani Scott Farmer, Joseph DeLuca and 11 more

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Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

21 authors.

Michaela LucasNational Allergy Council, Sydney, Australia.
Jillian KehoeNational Allergy Council, Sydney, Australia.
Samantha StilesNational Allergy Council, Sydney, Australia.
Sandra M SalterNational Allergy Centre of Excellence, Melbourne, Australia.
Jacqueline LopreteNational Allergy Centre of Excellence, Melbourne, Australia.
Catherine J HornungNational Allergy Centre of Excellence, Melbourne, Australia.
Lara MartinAustralasian Society of Clinical Immunology and Allergy, Sydney, Australia.
Syed B AliDepartment of Clinical Immunology and Allergy, Flinders Medical Centre, Adelaide, Australia.
Rani Scott FarmerNational Allergy Centre of Excellence, Melbourne, Australia.
Joseph DeLucaAustin Health, Melbourne, Australia.
Suran FernandoRoyal North Shore Hospital, Sydney, Australia.
Constance KatelarisWestern Sydney University, Sydney, Australia.
Helen KolawolePeninsula University Hospital, Melbourne, Australia.
Jason TrubianoNational Allergy Centre of Excellence, Melbourne, Australia.
Kirsten P PerrettNational Allergy Centre of Excellence, Melbourne, Australia.
William SmithNational Allergy Council, Sydney, Australia.
Francis ThienAustralasian Society of Clinical Immunology and Allergy, Sydney, Australia.
Jennifer J KoplinNational Allergy Centre of Excellence, Melbourne, Australia.
Sandra ValeNational Allergy Council, Sydney, Australia.
James YunAustralasian Society of Clinical Immunology and Allergy, Sydney, Australia.
National Allergy Council Drug Allergy consortium∗

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This guideline was developed in collaboration with the Australasian Society of Clinical Immunology and Allergy (ASCIA), the National Allergy Council and the National Allergy Centre of Excellence (NACE). Despite the abundance of published penicillin allergy guidelines, few have been developed using rigorous evidence-based approaches such as the AGREE II framework. Objective: This guideline aims to provide recommendations for the assessment and management of adults with a penicillin allergy label, for Australian health professionals working in both community and specialist settings. Methods: The guideline was developed using the standardized, evidence-based AGREE II framework, consumer input, and a Delphi-based consensus process, involving a multidisciplinary panel of 27 drug allergy experts. Recommendations were informed by a rapid overview of reviews and existing guidelines. Results: A total of 37 recommendations reached consensus, covering risk stratification, testing protocols, challenge test outcomes, and communication and documentation process. Conclusions: These adult guidelines will support the implementation of penicillin allergy delabeling programs in community and specialist centers in Australia. As high-level evidence supporting many recommendations in this field remains limited, a Delphi-based expert consensus approach provides valuable guidance.

Indexed as

delabelingdrug challengePenicillin allergyrisk stratification

Identifiers

PMID42908540
PMCPMC13683019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.