Evidence map›Paper›PMID 42908099›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Cerebral blood flow as a biomarker of resilience in cognitively unimpaired APOE ɛ4 carriers.

Melanie Quiring, Arunima Kapoor, John Paul M Alitin, Basant Lashin, Jillian L Joyce, Allison C Engstrom, Trevor Lohman, Aimée Gaubert, Fatemah Shenasa, Kevin W Law and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Melanie QuiringLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-2997-1105
Arunima KapoorDepartment of Psychological Science, University of California, Irvine, California, USA.
John Paul M AlitinLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Basant LashinLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Jillian L JoyceLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Allison C EngstromDepartment of Psychological Science, University of California, Irvine, California, USA.
Trevor LohmanKeck School of Medicine, University of Southern California, Los Angeles, California, USA.
Aimée GaubertLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Fatemah ShenasaDepartment of Psychological Science, University of California, Irvine, California, USA.
Kevin W LawLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Farrah FerrerLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Danny J J WangStevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California, USA.
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Medical Sciences D, Irvine, California, USA.
Rond MalhasDepartment of Neurology, University of California, Irvine, Irvine, California, USA.
Kathleen RodgersCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, Arizona, USA.
S Duke HanDepartment of Psychology, University of Southern California, Dornsife College of Arts and Letters, Los Angeles, California, USA.
Daniel A NationLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-9123-0658

Funding

Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2016 to 2026
$28.4M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
RESEARCH TRAINING IN GERONTOLOGYT32AG000037 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, EILEEN M CRIMMINS · 1985 to 2026
$13.2M
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineR01AG082073 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONDI, MARK W, MATHER, MARA · 2023 to 2025
$4.9M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Resource Core 3 (RC3), Data ScienceP30AG094848 · NIA · CEDARS-SINAI MEDICAL CENTER · PI Susan Cheng · 2025 to 2026
$4.0M
Sex Differences in Multi-omic and System-Specific AgingU54AG099000 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, EILEEN M CRIMMINS · 2026 to 2026
$3.0M
Mid-Career Development and Mentoring on Financial Vulnerability and Alzheimer's DiseaseK24AG081325 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DUKE HAN · 2023 to 2026
$798k
American Heart Association 23PRE1014192American Heart Association 26PRE1561693NIA NIH HHS T32AG000037NIH HHS K24AG081325NIH HHS P01AG052350NIH HHS P30AG066530NIH HHS P30AG094848NIH HHS R01AG064228NIH HHS R01AG082073NIH HHS U54AG099000
6 · The paper itself

Abstract

introductionIt remains unclear whether medial temporal lobe (MTL) hyperperfusion in cognitively unimpaired apolipoprotein E (APOE) ɛ4 carriers reflects resilience or dysfunction. We examined whether cortical MTL cerebral blood flow (CBF) relates to cognition differently in APOE ɛ4 carriers and noncarriers with and without AD pathophysiological changes.

methodsOne hundred forty-eight cognitively unimpaired older adults underwent pseudo-continuous arterial spin labeling MRI to quantify MTL CBF and assessment of memory and executive function. In a subset (n = 126), AD pathology was indexed using plasma phosphorylated tau 217 (pTau

resultsAPOE ɛ4 carriers showed higher MTL CBF than noncarriers. Higher MTL CBF was associated with better executive function only in pTau DISCUSSION: Hyperperfusion in cognitively unimpaired APOE ɛ4 carriers may reflect a resilience biomarker related to better cognitive function in the absence of detectable AD pathophysiological changes. HIGHLIGHTS: Apolipoprotein E (APOE) ɛ4 carriers show elevated medial temporal lobe (MTL) cerebral blood flow (CBF). Higher MTL CBF is linked to better executive function in APOE ɛ4 carriers. This association is only observed in APOE ɛ4 carriers who are pTau

Indexed as

Apolipoprotein E4Cerebrovascular CirculationCognitionTemporal LobeAgedAlzheimer DiseaseBiomarkersExecutive FunctionFemaleHeterozygoteHumansMagnetic Resonance ImagingMaleNeuropsychological Teststau ProteinsApolipoprotein E4Biomarkerstau ProteinsAPOEcerebral blood flowcognitive resilienceexecutive functionhyperperfusionplasma p‐tau217preclinical Alzheimer's disease

Identifiers

PMID42908099
PMCPMC13687585

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.