Evidence map›Paper›PMID 42908025›Full record

ArticleActa neuropathologica communications2026

Acetaminophen-induced liver injury triggers short- and long-term neuroinflammation, blood-brain barrier disruption, and behavioral deficits in a genetic mouse model of autism.

Jakub Szabó, Andrej Feješ, Ladislav Bačiak, Gabriela Fujeríková, Emese Renczés, Daniel Gogola, Youssef Zaim Wadghiri, Daniela Ostatníková, Peter Celec

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jakub SzabóInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Sasinkova 4, Bratislava, 811 08, Slovakia.
Andrej FeješInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Sasinkova 4, Bratislava, 811 08, Slovakia.
Ladislav BačiakCentral Laboratories, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 813 27, Bratislava, Slovakia.
Gabriela FujeríkováInstitute of Forensic Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Emese RenczésInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Sasinkova 4, Bratislava, 811 08, Slovakia.
Daniel GogolaDepartment of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia.
Youssef Zaim WadghiriDepartment of Radiology, Center for Advanced Imaging Innovation and Research (CAI2R) & Bernard and Irene Schwartz Center for Biomedical Imaging, New York University Grossman School of Medicine, New York City, NY, USA.
Daniela OstatníkováInstitute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Peter CelecInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Sasinkova 4, Bratislava, 811 08, Slovakia. peter.celec@uniba.sk.

Funding

Agentúra na Podporu Výskumu a Vývoja APVV-20-0070Agentúra na Podporu Výskumu a Vývoja APVV-22-0554Agentúra na Podporu Výskumu a Vývoja, Slovakia APVV-21-0299Agentúra na Podporu Výskumu a Vývoja, Slovakia APVV-21-0355
6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition with a strong genetic basis, yet its etiology is not fully understood. Neuroinflammation is emerging as a critical secondary factor. Since peripheral organ injury, such as acute liver failure, can induce neuroinflammation, we aimed to investigate whether liver injury could exacerbate ASD-like phenotypes in a genetically susceptible model. We used adult (12-month-old) Shank3

Indexed as

AcetaminophenAnalgesics, Non-NarcoticAutism Spectrum DisorderBlood-Brain BarrierChemical and Drug Induced Liver InjuryNeuroinflammatory DiseasesAnimalsBehavior, AnimalBrain EdemaDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsAcetaminophenAnalgesics, Non-NarcoticNerve Tissue ProteinsCerebral vasoreactivityDrug-induced liver InjuryHepatic encephalopathyParacetamolPhelan McDermid syndrome

Identifiers

PMID42908025
PMCPMC13689081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.