ArticleBMC pediatrics2026
Post-hemorrhagic ventricular dilatation and hydrocephalus in preterm infants: a five-year retrospective cohort study from a tertiary referral center.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-hemorrhagic hydrocephalus (PHH) is a serious complication of intraventricular hemorrhage (IVH) in preterm infants and is associated with increased morbidity and mortality. Although neonatal risk factors are well described, the contribution of maternal and perinatal factors remains inconsistent across studies.
objectiveTo determine the incidence, clinical characteristics, and independent predictors of PHH among preterm neonates with IVH, and to evaluate early outcomes in a tertiary referral center.
methodsThis retrospective cohort study included preterm neonates (< 34 weeks' gestation or birth weight ≤ 1500 g) with ultrasound-confirmed IVH admitted to Namazi Hospital, Shiraz, Iran, between March 2019 and March 2024. Demographic, maternal, perinatal, and neonatal variables were extracted from medical records. PHH was defined as progressive ventricular dilatation following IVH. Univariable and multivariable logistic regression analyses were performed to identify independent predictors of PHH.
resultsAmong 507 neonates with IVH, 154 (30.4%) developed PHH. Infants with PHH had significantly lower birth weight and gestational age and higher rates of maternal diabetes and neonatal meningitis.Each 100-g increase in birth weight was associated with a 24% reduction in the odds of developing post-hemorrhagic hydrocephalus (OR 0.76; 95% CI 0.7-0.83; p < 0.001).Maternal gestational diabetes mellitus/diabetes was a significant risk factor (OR 2.14; 95% CI 1.39-3.29; p = 0.001) Antenatal steroid exposure was associated with lower odds of PHH, possibly reflecting reduced hemorrhage severity(OR 0.53; 95% CI 0.35-0.80; p = 0.003).Mortality was borderline higher among infants with PHH (p = 0.05), while the need for surgical intervention was significantly higher in this group (p < 0.001).The primary clinical model demonstrated good calibration (Hosmer-Lemeshow p = 0.19) and acceptable discrimination (AUC = 0.75).
conclusionPHH remains a frequent and severe complication of IVH in preterm neonates. Both neonatal and selected maternal factors contribute to PHH risk, underscoring the importance of comprehensive perinatal assessment and early identification of high-risk infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.