ArticleJournal of nanobiotechnology2026
Schwann cell-derived extracellular vesicles promote periodontal tissue regeneration.
Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Periodontitis is a common chronic inflammatory disease worldwide, and conventional therapies control inflammation but fail to achieve predictable regeneration. The inferior alveolar nerve (IAN) is a key peripheral nerve that governs mandibular bone homeostasis, and its disruption precipitates bone metabolic imbalance and impaired repair. However, the dynamic behavior of Schwann cells (SCs), the principal glial cells of this neural axis, and their mechanistic influence on periodontal ligament stem cells (PDLSCs) remain elusive. We established a rat IAN transection model and found that denervation induced progressive alveolar bone deterioration and compromised the osteogenic capacity of resident PDLSCs. Correlation analyses revealed that this bone deterioration coincided with progressive SC depletion in periodontal tissue, suggesting a link between Schwann cell loss and PDLSC dysfunction. Transcriptomic profiling of denervated PDLSCs revealed that dysregulated AMPK/mTOR signaling and suppressed autophagy are mechanisms underlying osteogenic impairment. Co-culture with SCs restored PDLSC proliferation and osteogenic differentiation, with SC-derived extracellular vesicles (SC-EVs) as important paracrine mediators of this effect. Mechanistically, SC-EVs delivered rno-miR-210-5p, which targeted the DAP1 gene and suppressed its expression, thereby activating the AMPK/mTOR-autophagy axis and rescuing osteogenic potential. In a rat denervated mandibular defect model, SC-EVs significantly enhanced bone regeneration. Collectively, these findings suggest that Schwann cells and their EVs participate in the neural regulation of periodontal bone metabolism and may play an important role in periodontal regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.