Evidence map›Paper›PMID 42907855›Full record

ArticleRespiratory research2026

Clinical, radiological, and pathological features of pulmonary hypertension associated with combined pulmonary fibrosis and emphysema.

Mengyu He, Qinhua Zhao, Huikang Xie, Rui Zhang, Jinming Liu, Weiping Xie, Yanzhe Yu, Yan Wu, Jiayi Zhang, Chunyan Wu and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Mengyu He *Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Qinhua Zhao *Department of Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, 200433, China.
Huikang Xie *Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, 200433, China.
Rui ZhangDepartment of Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, 200433, China.
Jinming LiuDepartment of Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, 200433, China.
Weiping XieDepartment of Pulmonary and Critical Care Medicine, the First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Yanzhe YuDepartment of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, 210008, China.
Yan WuDepartment of Pulmonary and Critical Care Medicine, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu, 214023, China.
Jiayi ZhangDepartment of Ultrasound, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, 210008, China.
Chunyan WuDepartment of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, 200433, China. wuchunyan581@163.com.
Sugang GongDepartment of Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, 200433, China. gongsugang@tongji.edu.cn.
Lan WangDepartment of Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, 200433, China. lanwang@tongji.edu.cn.

Funding

Clinical Research Project of Shanghai Pulmonary Hospital FKLY20005National Key Research and Development Program of China 2023YFC2507200National Natural Science Foundation of China 82000061National Natural Science Foundation of China 82241010National Natural Science Foundation of China 82570074
6 · The paper itself

Abstract

backgroundCombined pulmonary fibrosis and emphysema-associated pulmonary hypertension (CPFE-PH) has emerged as a distinct third category of PH, yet its detailed clinical-hemodynamic profile, pathological features, and comparative outcomes remain poorly defined. This study aims to characterize the phenotype of CPFE-PH and compare it with chronic obstructive pulmonary disease-related PH (COPD-PH) and idiopathic interstitial pneumonia-related PH (IIP-PH).

methodsIn this multicenter cohort study, we analyzed 113 patients with CPFE-PH, 277 with COPD-PH, and 78 with IIP-PH, all diagnosed by right heart catheterization. Clinical, physiological, imaging, pathological, treatment response, and survival data were statistically compared across groups.

resultsCPFE-PH patients were older, predominantly male smokers, and exhibited preserved ventilatory function but severely reduced diffusing capacity (DL

conclusionsCPFE-PH appears to represent a severe phenotype within Group 3 PH, in which prominent capillary remodeling, including hemangiomatosis-like changes, may contribute to its clinical, radiological, and functional manifestations, distinguish it from other Group 3 PH types. CLINICAL TRIAL: Chinese Clinical Study.org, No: ChiCTR2000032212, Registration Date: 2020-04-23; URL: http://www.chictr.org.cn/ .

Indexed as

Hypertension, PulmonaryPulmonary EmphysemaPulmonary FibrosisAgedCohort StudiesFemaleHumansMaleMiddle AgedCapillary hemangiomatosis-like lesionsCombined pulmonary fibrosis and emphysemaHemodynamicsPulmonary hypertensionPulmonary hypertension associated with chronic lung diseases

Identifiers

PMID42907855
PMCPMC13689075

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.