ArticleBMC pediatrics2026
Initial response and long-term prognostic risk factors in pediatric ITP.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo explore the clinical features and prognostic factors for initial response and long-term prognosis of pediatric immune thrombocytopenia (ITP).
methodA retrospective cohort study of 910 cases of pediatric patients with ITP was conducted. Demographic data, platelet counts, triggers, bleeding grades, glucocorticoid (GC) tapering time, IVIG status and treatment outcomes were collected. Initial response was defined as a platelet counts ≥ 30 × 10
resultsGC tapering time (OR = 0.39, 95% CI:0.16-0.91, p = 0.03) and bleeding grade 5 (OR = 0.26, 95% CI:0.11-0.52, p < 0.001) were significantly associated with initial response. Age ≥ 3 years (OR = 1.83, 95% CI: 1.18-2.84, p = 0.007) was identified as an independent risk factor for long-term prognosis of pediatric ITP. RCS analysis revealed a nonlinear association between age and the progression of persistent and chronic ITP (p = 0.0012), with two inflection points at approximately 3.75 and 8 years. The risk of progression increased rapidly before 3.75 years, stabilized between 3.75 and 8 years, and rose sharply thereafter, indicating that age ≥ 8 years was at particularly high risk. Neither IVIG administration (OR = 0.99, 95% CI: 0.65-1.53, p = 0.98) nor GC tapering time ≥ 7 days (OR = 1.62, 95% CI: 0.76-3.43, p = 0.21) was significantly associated with long-term prognosis.
conclusionAge was an independent risk factor for progression to persistent and chronic ITP. Short-course GC regimens could be a rational therapeutic alternative for pediatric ITP patients without severe manifestations or life-threatening bleeding, and age-stratified risk management merits clinical consideration.
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