ArticleIndian journal of pediatrics2026
Efficacy of Vitamin D Supplementation in Children with Transfusion Dependent Thalassemia.
Article in Indian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesHypovitaminosis D is common in children with transfusion-dependent thalassemia (TDT) because of chronic iron overload and endocrine dysfunction. This study assessed baseline vitamin D status, response to supplementation, and factors associated with treatment response and maintenance of sufficiency.
methodsIn this prospective observational study, children aged 1-18 y with TDT underwent assessment of demographic, clinical, biochemical, and serum 25-hydroxyvitamin D levels. Vitamin D deficiency, insufficiency, and sufficiency were defined as <12 ng/mL, 12-20 ng/mL, and >20 ng/mL, respectively. Children with deficient or insufficient levels received oral vitamin D (60,000 IU weekly for 6 wk) with calcium supplementation. Vitamin D levels were reassessed after 3 mo; non-responders received repeat supplementation, while responders were followed for maintenance of sufficiency.
resultsAmong 93 children, 89 (95.7%) had hypovitaminosis D, with a mean baseline vitamin D level of 11.63 ± 5.66 ng/mL. Following supplementation, 60 (67.4%) achieved sufficiency, while 29 (32.6%) remained deficient/insufficient. Of those achieving sufficiency, only 14 (23.3%) maintained adequate levels at 3-mo follow-up, whereas 46 (76.7%) again became deficient/insufficient. Repeat supplementation resulted in sufficiency in 20/29 (69.0%) children. Baseline vitamin D levels showed a significant negative correlation with serum ferritin (ρ = -0.664, p <0.001).
conclusionsHypovitaminosis D is highly prevalent in children with TDT and is strongly associated with iron overload. Although supplementation effectively improves vitamin D levels, maintenance of sufficiency after discontinuation remains poor, emphasizing the need for regular monitoring and maintenance supplementation.
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