Evidence map›Paper›PMID 42907721›Full record

ArticleJournal of neuro-oncology2026

Neighborhood material deprivation and days at home after glioblastoma diagnosis.

Jasleen Saini, Christopher Lozano, Vishwathsen Karthikeyan, Husain Shakil, Armaan K Malhotra, Yingshi He, Jenna Sykes, Mary Jane Lim-Fat, Jetan Badhiwala, Jefferson R Wilson and 1 more

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Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Jasleen SainiDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada. jas.saini@mail.utoronto.ca.ORCID http://orcid.org/0009-0009-3389-3101
Christopher LozanoDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Vishwathsen KarthikeyanDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Husain ShakilDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Armaan K MalhotraDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Yingshi HeDivision of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Jenna SykesInstitute of Health Policy Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Mary Jane Lim-FatDivision of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Jetan BadhiwalaDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Jefferson R WilsonDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Saira B AlliDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the association between neighborhood material deprivation and days at home (DAH) after glioblastoma diagnosis.

methodsThis population-based retrospective cohort study used linked administrative data from Ontario, Canada, for adults diagnosed with glioblastoma during 2003-2023. Material deprivation was assigned using Ontario Marginalization Index quintiles (Q1, least deprived; Q5, most deprived). The primary outcome was DAH within 365 days, defined as days alive outside acute hospitals, inpatient rehabilitation, and continuing or complex care. The primary analysis included diagnoses through 2022. Median quantile regression adjusted for age, sex, comorbidity, frailty, rurality, and diagnosis year. Secondary outcomes included other DAH horizons and overall survival.

resultsAmong 9172 adults, 4491 (49.0%) were younger than 65 years and 5435 (59.3%) were male. Median DAH-365 was 249 days (interquartile range, 67-350) in Q1 and 138 (27-332) in Q5. In 8234 complete cases, adjusted median differences versus Q1 were - 8.8 days for Q2 (95% confidence interval [CI], - 19.6 to 2.0), - 14.8 for Q3 (- 27.0 to - 2.6), - 18.3 for Q4 (- 29.4 to - 7.2), and - 36.2 for Q5 (- 51.5 to - 20.9). Median survival was 324 days (95% CI, 306-343) in Q1 and 225 (211-244) in Q5.

conclusionGreater neighborhood material deprivation was associated with substantially fewer DAH after glioblastoma diagnosis. The adjusted gap exceeding 5 weeks supports investigation of treatment access and supportive care pathways to inform efforts to improve equity.

Indexed as

Brain NeoplasmsGlioblastomaNeighborhood CharacteristicsResidence CharacteristicsAdultAgedFemaleHumansMaleMiddle AgedOntarioRetrospective StudiesDays at homeGlioblastomaHealth equityMaterial deprivationPopulation-based cohortSocioeconomic disparities

Identifiers

PMID42907721

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.