ReviewAdvances in experimental medicine and biology2026
Application of Ion Mobility Mass Spectrometry in Lipidomics.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Lipids play significant roles in biological systems, and the study of lipid metabolism may provide a new insight into the diagnosis and pathophysiology of diseases. Recent developments in high-resolution mass spectrometry techniques combined with high-performance chromatographic methods provide deep insight into lipid analysis. Addition of ion mobility mass spectrometry orthogonal to LC-MS analysis workflow enhances the separation of complex lipids, improves isomer resolution, and increases confidence in lipid identification and characterization. In this chapter, we describe the principle of traveling wave ion mobility mass spectrometry (TWIMS) and its applications in untargeted LC-MS analysis for characterizing the structural diversity and complexity of lipid species in biological samples.
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