Evidence map›Paper›PMID 42907647›Full record

ReviewAdvances in experimental medicine and biology2026

Mass Spectrometry- and Structural Biology-Based Investigation of Proteins.

Pathea S Bruno, Taniya M Jayaweera, Aneeta Arshad, Victor T Njoku, Stephanie Andreescu, Zachary Ely, Izabela Sokolowska, Anca-Narcisa Neagu, Costel C Darie

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pathea S Bruno *Biochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, USA.
Taniya M Jayaweera *Biochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, USA.
Aneeta ArshadBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, USA.
Victor T NjokuBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, USA.
Stephanie AndreescuBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, USA.
Zachary ElyBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, USA.
Izabela SokolowskaBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, USA.
Anca-Narcisa NeaguLaboratory of Animal Histology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iaşi, Iasi, Romania.
Costel C DarieBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, USA. cdarie@clarkson.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent developments in mass spectrometry (MS) allow us to identify, estimate, and characterize proteins and protein complexes. At the same time, structural biology helps to determine the protein structure and its structure-function relationship. Together, they aid to understand the protein structure, property, function, protein-complex assembly, protein-protein interaction, and dynamics. Here, we present illustrative data that demonstrate how experimental MS can be combined with computational structural biology for detailed studies of protein structures. To investigate possible protein conformations, we focus on five proteins-lysozyme, chymotrypsin, myoglobin, desmin, and hemoglobin.

Indexed as

Mass SpectrometryProteinsAnimalsChymotrypsinComputational BiologyDesminHumansModels, MolecularMyoglobinProtein ConformationChymotrypsinDesminMyoglobinProteinsMass spectrometryProtein complexProtein conformationProtein–protein interactionsStructural biology

Identifiers

PMID42907647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.