Evidence map›Paper›PMID 42907639›Full record

ReviewAdvances in experimental medicine and biology2026

A Proteomic Glance at the Bovine Intervertebral Disc.

Kangning Li, Devika Channaveerappa, Costel C Darie, Thomas Lufkin, Petra Kraus

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kangning LiDepartment of Biology, Clarkson University, Potsdam, NY, USA.
Devika ChannaveerappaBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 13699, USA.
Costel C DarieBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 13699, USA.
Thomas LufkinDepartment of Biology, Clarkson University, Potsdam, NY, USA.
Petra KrausDepartment of Biology, Clarkson University, Potsdam, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trauma- or age-inflicted intervertebral disc (IVD) degeneration (IVDD) is a leading cause of chronic and severe low back pain. Raising interest in regenerative, cell-based therapies depends on a solid understanding of cell identities and their natural habitat, most importantly the extracellular matrix (ECM) composition. We and others previously proposed IVD biomarkers to characterize IVD cells. To complement our transcriptome data, we also investigated the proteome of the annulus fibrosus (AF) and nucleus pulposus (NP) bovine coccygeal tissue via nano liquid chromatography electrospray ionization tandem quadrupole time-of-flight mass spectrometry (nano LC-ESI-qTOF-MS). The mature bovine coccygeal IVD is an accepted animal model to study IVD homeostasis. We performed both qualitative and quantitative analyses, identifying proteins involved with ECM homeostasis and metabolism. We discuss this information in relation to our previously published 2D in vitro transcriptome data and in the context of other significant progress made in the IVD omics field.

Indexed as

Intervertebral DiscIntervertebral Disc DegenerationProteomeProteomicsAnimalsAnnulus FibrosusBiomarkersCattleExtracellular MatrixNucleus PulposusBiomarkersProteomeAnnulus fibrosusIntervertebral discMass spectrometryNucleus pulposusProteomics

Identifiers

PMID42907639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.