ReviewAdvances in experimental medicine and biology2026
Harnessing ICP-MS for Quantitative Analysis of Metal-Based Nanoparticle-Cell Interactions.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
The increasing use of metal-based nanoparticles in biomedical and environmental applications has intensified the need for advanced analytical strategies capable of elucidating their interactions with biological systems. Inductively coupled plasma mass spectrometry (ICP-MS) has emerged as a powerful and versatile tool for the quantitative analysis of nanoparticle-cell interactions owing to its sensitivity, selectivity, and multielement capability. This chapter provides a comprehensive review of recent developments in ICP-MS-based technologies for investigating cellular uptake, intracellular distribution and biotransformation of metal-containing nanoparticles. Approaches ranging from conventional bulk analysis to single particle and single cell approaches are discussed, highlighting their respective strengths and limitations. The coupling of ICP-MS with separation techniques and emerging imaging and mass cytometry strategies is also presented, underscoring the critical role of ICP-MS in advancing nanotoxicology and nanomedicine research.
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Registered trials
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