Evidence map›Paper›PMID 42907621›Full record

ReviewAdvances in experimental medicine and biology2026

Mass Spectrometry for Proteomics-Based Investigation.

Pathea S Bruno, Izabela Sokolowska, Armand G Ngounou Wetie, Roshanak Aslebagh, Kelly L Wormwood, Devika Channaveerappa, Emmalyn J Dupree, Madhuri Jayathirtha, Danielle Whitham, Lawrence Tucker and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pathea S BrunoBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 23699-5810, USA.
Izabela SokolowskaBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 23699-5810, USA.
Armand G Ngounou WetieBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 23699-5810, USA.
Roshanak AslebaghBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 23699-5810, USA.
Kelly L WormwoodBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 23699-5810, USA.
Devika ChannaveerappaBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 23699-5810, USA.
Emmalyn J DupreeBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 23699-5810, USA.
Madhuri JayathirthaBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 23699-5810, USA.
Danielle WhithamBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 23699-5810, USA.
Lawrence TuckerBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 23699-5810, USA.
Celeste A DarieBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 23699-5810, USA.
Alisa G WoodsBiochemistry and Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, 23699-5810, USA. awoods@clarkson.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Within the past years, we have witnessed a great improvement in mass spectrometry (MS) and proteomics approaches in terms of instrumentation, protein fractionation, and bioinformatics. With the current technology, protein identification alone is no longer sufficient. Both scientists and clinicians want not only to identify the proteins but also to identify the proteins' post-translational modifications (PTMs), protein isoforms, protein truncation, protein-protein interactions (PPI), and protein quantitation. Here, we describe the principles of MS and proteomics and strategies to identify proteins, proteins' PTMs, protein isoforms, protein truncation, PPIs, and protein quantitation. We also discuss the strengths and weaknesses within this field. Finally, in our concluding remarks, we assess the role of mass spectrometry and proteomics in the scientific and clinical settings in the near future. This chapter provides an introduction and overview for subsequent chapters that will discuss specific MS proteomic methodologies and their application to specific medical conditions. Other chapters will also touch upon areas that expand beyond proteomics, such as lipidomics and metabolomics.

Indexed as

Mass SpectrometryProteinsProteomicsAnimalsHumansProtein Interaction MappingProtein Processing, Post-TranslationalTandem Mass SpectrometryProteinsLC-MS/MSMALDI-MSMass spectrometryPost-translational modificationsProteomics

Identifiers

PMID42907621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.