Evidence map›Paper›PMID 42907516›Full record

ArticleNature2026

Programmable design of functional proteins from natural language.

Fengyuan Dai, Shiyang You, Yudian Zhu, Yuan Gao, Lihao Fu, Xibin Zhou, Jin Su, Chentong Wang, Yuliang Fan, Qingsong Tan and 23 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Fengyuan Dai *School of Engineering, Westlake University, Hangzhou, China.
Shiyang You *Bioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China.
Yudian ZhuSchool of Engineering, Westlake University, Hangzhou, China.
Yuan GaoState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Lihao FuState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Xibin ZhouSchool of Engineering, Westlake University, Hangzhou, China.
Jin SuSchool of Engineering, Westlake University, Hangzhou, China.
Chentong WangSchool of Life Sciences, Westlake University, Hangzhou, China.
Yuliang FanSchool of Engineering, Westlake University, Hangzhou, China.
Qingsong TanSchool of Engineering, Westlake University, Hangzhou, China.
Xiaoxiao MaBioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China.
Xianjun DengBioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China.
Letong YuBioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China.
Hui QianSchool of Engineering, Westlake University, Hangzhou, China.
Yan HeSchool of Life Sciences, Westlake University, Hangzhou, China.
Yitao KeSchool of Life Sciences, Westlake University, Hangzhou, China.ORCID http://orcid.org/0009-0002-1231-7438
Zhe ZhangSchool of Engineering, Westlake University, Hangzhou, China.
Chenchen HanSchool of Engineering, Westlake University, Hangzhou, China.
Xing ChangSchool of Life Sciences, Westlake University, Hangzhou, China.ORCID http://orcid.org/0000-0002-5072-9225
Liangzhen ZhengShanghai Zelixir Biotech, Shanghai, China.ORCID http://orcid.org/0000-0003-1179-2106
Sheng WangShanghai Zelixir Biotech, Shanghai, China.
Yuan JiState Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin, China.
Kexin HaoState Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin, China.
Longxing CaoSchool of Life Sciences, Westlake University, Hangzhou, China.ORCID http://orcid.org/0000-0003-4002-3648
Yajie WangSchool of Engineering, Westlake University, Hangzhou, China.ORCID http://orcid.org/0000-0002-6216-791X
Anping ZengSchool of Engineering, Westlake University, Hangzhou, China.ORCID http://orcid.org/0000-0001-9768-7096
Shunzhi WangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5033-7478
Chunjun ZhanSchool of Engineering, Westlake University, Hangzhou, China.
Jing ZhaoState Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin, China.
Tong SiState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. tong.si@siat.ac.cn.ORCID http://orcid.org/0000-0003-2985-9014
Jianming LiuSchool of Engineering, Westlake University, Hangzhou, China. liujianming@westlake.edu.cn.ORCID http://orcid.org/0000-0001-6527-6049
Hongyuan LuBioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China. hongylu@hkust-gz.edu.cn.ORCID http://orcid.org/0000-0001-9763-7865
Fajie YuanSchool of Engineering, Westlake University, Hangzhou, China. yuanfajie@westlake.edu.cn.ORCID http://orcid.org/0000-0001-8452-9929

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Programming biological function-designing bespoke proteins to perform specified molecular tasks-is a foundational goal of molecular engineering. However, current design models remain fundamentally limited

Identifiers

PMID42907516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.