Evidence map›Paper›PMID 42907504›Full record

ArticleNature2026

WEE1 opposes APC/C

Luc-Alban Vuillemenot, Lucas G Morales, Calin-Mihai Dragoi, Betheney R Pennycook, Edward Harris, Liuyang C Lin, William A Weston, Jade-Ellen Brown, Emma Graham, Leelou Moulin and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Luc-Alban Vuillemenot *Institute of Clinical Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-5693-7199
Lucas G Morales *MRC Laboratory of Medical Sciences, London, UK.
Calin-Mihai Dragoi *Department of Biochemistry, University of Oxford, Oxford, UK.
Betheney R PennycookInstitute of Clinical Sciences, Imperial College London, London, UK.
Edward HarrisMRC Laboratory of Medical Sciences, London, UK.ORCID http://orcid.org/0009-0000-9219-9165
Liuyang C LinMRC Laboratory of Medical Sciences, London, UK.ORCID http://orcid.org/0009-0001-0571-9693
William A WestonMRC Laboratory of Medical Sciences, London, UK.
Jade-Ellen BrownMRC Laboratory of Medical Sciences, London, UK.
Emma GrahamMRC Laboratory of Medical Sciences, London, UK.
Leelou MoulinMRC Laboratory of Medical Sciences, London, UK.
Ivan AndrewMRC Laboratory of Medical Sciences, London, UK.
Georgia RoumeliotiMRC Laboratory of Medical Sciences, London, UK.
Alex MontoyaMRC Laboratory of Medical Sciences, London, UK.ORCID http://orcid.org/0000-0002-6501-883X
Laurence GameMRC Laboratory of Medical Sciences, London, UK.
George R YoungMRC Laboratory of Medical Sciences, London, UK.ORCID http://orcid.org/0000-0002-1203-588X
Keshava K DattaMRC Laboratory of Medical Sciences, London, UK.ORCID http://orcid.org/0000-0002-4322-5491
Pavel ShliahaMRC Laboratory of Medical Sciences, London, UK.
Béla NovákDepartment of Biochemistry, University of Oxford, Oxford, UK.
Hiroyuki YamanoUniversity College London Cancer Institute, London, UK.
Alexis R BarrInstitute of Clinical Sciences, Imperial College London, London, UK. abarr@ic.ac.uk.ORCID http://orcid.org/0000-0002-6684-8114

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

WEE1 phosphorylates and inhibits the activity of cyclin-dependent kinases to prevent mitotic entry and establish a G2 DNA damage checkpoint

Identifiers

PMID42907504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.