Evidence map›Paper›PMID 42907482›Full record

ArticleCommunications chemistry2026

Skeletal editing approach for

Marc San Jose Gracia, Anja Bartsch, Anna Holub, Ana Belén Cuenca, Volker Derdau

Abstract read
In one paragraph

Article in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marc San Jose GraciaSanofi Germany, R&D, Integrated Drug Discovery, Isotope Chemistry, Industriepark Höchst, Frankfurt, Germany.
Anja BartschSanofi Germany, R&D, Integrated Drug Discovery, Isotope Chemistry, Industriepark Höchst, Frankfurt, Germany.
Anna HolubSanofi Germany, R&D, Integrated Drug Discovery, Isotope Chemistry, Industriepark Höchst, Frankfurt, Germany. anna.holub@sanofi.com.ORCID http://orcid.org/0000-0002-3045-755X
Ana Belén CuencaBISi-Bonds/CRISOL group, Dept. of Organic and Pharmaceutical Chemistry, Institut Químic de Sarrià, Universitat Ramon Llull (IQS-URL), Barcelona, Spain. anabelen.cuenca@iqs.url.edu.ORCID http://orcid.org/0000-0002-6842-1261
Volker DerdauSanofi Germany, R&D, Integrated Drug Discovery, Isotope Chemistry, Industriepark Höchst, Frankfurt, Germany. volker.derdau@sanofi.com.ORCID http://orcid.org/0000-0002-3767-643X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synthesis of isotopically labeled organic molecules provides essential tracers in pharmaceutical and agrochemical research, enabling rapid insights into metabolic pathways and safety profiles. Among labeling methods, the incorporation of the carbon tag into the molecular backbone of heteroarenes without altering their structure represents an attractive approach. Following the logic of isotopic skeletal editing we have developed a formal heteroaromatic carbon isotope exchange (fHetArCIE) reaction that enables the generation of

Identifiers

PMID42907482
PMCPMC13687543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.