Evidence map›Paper›PMID 42907447›Full record

ArticleNature communications2026

Unveiling structural determinants of peptide recognition by public and private SARS-CoV-2-specific T-cell receptors.

Caner Akıl, Yanchun Peng, Julia McCarthy, Yanan Zhu, Nathan Hardenbrook, Yunkai Yang, Danning Dong, Elie Antoun, Xuan Yao, Guihai Liu and 8 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Caner Akıl *Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-9464-1903
Yanchun Peng *Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-2340-0499
Julia McCarthy *Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Yanan Zhu *Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-1025-7929
Nathan HardenbrookDivision of Structural Biology, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Yunkai YangChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-2240-807X
Danning DongChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Elie AntounChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-9477-1564
Xuan YaoChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Guihai LiuChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0009-0003-3684-4870
Ji-Li ChenChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Esra BalıkçıDivision of Structural Biology, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0009-0000-9160-5790
Raul CioacaChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Alexander J MentzerChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-4502-2209
Julian C KnightChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-0377-5536
Ricardo A FernandesChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK. ricardo.fernandes@ndm.ox.ac.uk.ORCID 0000-0001-5343-3334
Tao DongChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK. tao.dong@ndm.ox.ac.uk.ORCID 0000-0003-3545-3758
Peijun ZhangChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK. peijun.zhang@strubi.ox.ac.uk.ORCID 0000-0003-1803-691X

Funding

Project 3. IntegrationU54AI170791 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Zandrea Ambrose · 2022 to 2026
$30.6M
Correlative cryoET of the HIV-1 integration targeting in native T-lymphocytesR21AI184080 · NIAID · UNIVERSITY OF OXFORD · PI ZHANG, PEIJUN · 2024 to 2025
$285k
Chinese Academy of Medical Sciences (CAMS) 2024-I2M-2-001-1EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101021133NIAID NIH HHS R21 AI184080NIAID NIH HHS U54 AI170791Wellcome Trust 203141/Z/16/ZWellcome Trust (Wellcome) 311427/Z/24/Z
6 · The paper itself

Abstract

Public T cell receptors (TCRs) recurrently emerge across individuals in response to common pathogens, yet the structural and biophysical basis distinguishing public from private clonotypes remains incompletely defined. Here, we combine epitope mapping, single-cell TCR sequencing, and single-particle cryo-electron microscopy to dissect CD8

Indexed as

PeptidesReceptors, Antigen, T-CellSARS-CoV-2CD8-Positive T-LymphocytesCOVID-19Cryoelectron MicroscopyEpitope MappingEpitopes, T-LymphocyteHumansEpitopes, T-LymphocytePeptidesReceptors, Antigen, T-Cell

Identifiers

PMID42907447
PMCPMC13687542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.