Evidence map›Paper›PMID 42907445›Full record

ArticleNature communications2026

Multichannel, biomimetic scaffolds improve functional connectivity following traumatic long-gap peripheral nerve injury.

Jacob Koffler, Eleni Sinopoulou, Isac Lazarovits, Deborah M W Alexander, Alec Salcido, Kendell Pawelec, Reid Abrams, Jeff Sakamoto, Mark H Tuszynski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jacob KofflerDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA. ykoffler@ucsd.edu.ORCID 0000-0002-8415-2938
Eleni SinopoulouDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA.
Isac LazarovitsDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA.
Deborah M W AlexanderDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA.
Alec SalcidoDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA.
Kendell PawelecDepartment of Radiology & Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, USA.
Reid AbramsDepartment of Orthopedics, University of California San Diego, La Jolla, CA, USA.
Jeff SakamotoMaterials Department, University of California Santa Barbara, Santa Barbara, CA, USA.
Mark H TuszynskiDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-4182-1481

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gold standard for repair of peripheral nerve injuries is a nerve autograft. Donor nerve harvest creates a second surgical site, invariable numbness and donor site chronic neuropathic pain in 20% of cases. We developed a poly-caprolactone (PCL) multichannel, biomimetic scaffold with surface features promoting cell and vascular attachment and rapid, linear axonal regeneration. The cross-sectional area available for axonal regeneration exceeds that of autografts. When compared to nerve autografts and FDA-approved nerve conduits in 1cm-long rat and 3cm-long rabbit sciatic gap injury, biomimetic scaffolds were equivalent or superior to nerve autografts on measures of axonal regeneration, re-connection between gastrocnemius muscle and spinal cord motor neurons, and evoked motor responses. Scaffolds were superior in all measures to open tube conduits. Biomimetic multichannel scaffolds have potential to replace the need for autografting for peripheral nerve gap repair and are now undergoing multicenter clinical trials.

Indexed as

Biomimetic MaterialsNerve RegenerationPeripheral Nerve InjuriesTissue ScaffoldsAnimalsAxonsBiomimeticsFemaleMaleMotor NeuronsMuscle, SkeletalPolyestersRabbitsRatsRats, Sprague-DawleySciatic NervepolycaprolactonePolyesters

Identifiers

PMID42907445
PMCPMC13687026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.