Evidence map›Paper›PMID 42905958›Full record

ArticleJournal of applied clinical medical physics2026

Comparison of two close-packing methods for vertex placement in lattice radiotherapy (LRT).

Yingjie Song, Pan Ma, Jianrong Dai

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied clinical medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Yingjie SongDepartment of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Pan MaDepartment of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jianrong DaiDepartment of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Funding

National Natural Science Foundation of China GrantNo.11875320
6 · The paper itself

Abstract

backgroundLattice Radiation Therapy (LRT) is characterized by its 3D-mouldated spatial dose distribution of vertices inside the lattice volume with high peak-to-valley dose ratio (PVDR) for enhancing tumor control and reducing normal tissue toxicity. While face-centered cubic (FCC) and hexagonal close-packed (HCP), both achieving maximum spatial packing density, have been used for vertex placement, a direct comparative analysis of their dosimetric performance is lacking. PURPOSE: This study aimed to systematically compare FCC and HCP methods for vertex placement under identical conditions to determine which yields superior dosimetric outcomes, specifically regarding the peak-to-valley dose ratio (PVDR), and to provide data supporting the standardization of LRT planning. MATERIALS AND

methodsThis study was retrospectively conducted on 10 patients with large gross tumor volumes (GTV) (GTV; median [IQR] GTV volume: 916.59[609.37] cm

resultsVertex parameters (number, volume, spacing) showed no significant difference between Plan_FCC and Plan_HCP (P > 0.05). Dosimetric analysis revealed a statistically significant increase in PVDR (lattice volume D

conclusionsUnder matched radiation delivery technique, geometric constraints and identical dose-volume objectives, the FCC vertex arrangement yields a statistically significantly higher peak-to-valley dose ratio (lattice volume D

Indexed as

AlgorithmsNeoplasmsOrgans at RiskRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedHumansPrognosisRadiotherapy DosageRetrospective Studiesclose‐packing arrangementsface‐centered cubic (FCC)hexagonal close‐packed (HCP)lattice radiation therapy (LRT)peak‐to‐valley dose ratio (PVDR)vertices arrangement

Identifiers

PMID42905958
PMCPMC13686585

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