Observational studyCNS neuroscience & therapeutics2026
Impaired Dynamic Cerebral Autoregulation Across the REM Sleep Behavior Disorder Spectrum: Evidence From Isolated REM Sleep Without Atonia to Parkinson's Disease With RBD.
Observational study in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02752139 (Cerebral Hemodynamics in Sleep Disorders), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cerebral Hemodynamics in Sleep Disorders
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectivesRapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by REM sleep without atonia (RSWA) and dream-enactment behaviors and is recognized as a prodromal manifestation of α-synucleinopathies. Isolated RSWA (iRSWA) has been proposed as a potential early stage within the RBD spectrum, although its clinical and physiological significance remains incompletely understood. This study aimed to investigate alterations in sleep architecture, phasic muscle activity, and dynamic cerebral autoregulation (dCA) across the spectrum from iRSWA to isolated RBD (iRBD) and Parkinson's disease with RBD (PD + RBD).
methodsWe conducted a case-control study involving patients with iRSWA, iRBD, and PD + RBD, as well as age- and sex-matched healthy controls, based on video-polysomnography and magnetic resonance imaging. Scales for Outcomes in Parkinson's Disease-Autonomic Dysfunction (SCOPA-AUT) were used to evaluate the autonomic function. Transcranial Doppler and finger plethysmography were used to assess dCA by analyzing the phase difference using transfer function analysis.
resultsA total of 25 patients with iRSWA, 30 with iRBD, 28 with PD + RBD, and 30 healthy controls were included. REM sleep percentage was significantly lower in the iRBD and PD + RBD groups than in controls. Phasic RSWA, but not tonic RSWA, differed significantly among the three patient groups (p < 0.001). Phase difference was significantly lower in all three patient groups than in controls (p < 0.001) and was significantly associated with REM sleep amount and phasic RSWA (both p < 0.001).
conclusionsThese findings suggest that dCA is impaired in patients with iRSWA, iRBD, and PD + RBD. Reduced phase difference was associated with lower REM sleep amount and greater phasic RSWA, suggesting disrupted coupling among REM sleep regulation, autonomic function, and cerebrovascular control. dCA dysfunction may represent an early pathophysiological feature in RBD-related neurodegeneration.
trial registrationClinicalTrials.gov Identifier: NCT02752139.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.