ArticleMedical physics2026
Segment anything model (SAM)-driven prompt-guided interactive delineation of gross tumor volume for rectal cancer neoadjuvant radiotherapy.
Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSegment Anything Model (SAM), a prompt-guided foundation model, exhibits substantial potential for medical image segmentation by incorporating prior knowledge through user-defined prompts. However, the application of SAM in radiotherapy target delineation remains limited. PURPOSE: This study proposes a feasible prompt-guided interactive delineation workflow driven by an optimized SAM.
methodsA total of 100 rectal cancer neoadjuvant radiotherapy cases were collected (60 for training and 40 for testing). This study utilized bounding-box prompts to guide SAM for GTV segmentation. Physicians manually draw box prompts on certain slices, while box prompts for the remaining slices are automatically generated using an interpolation strategy. Four fine-tuning strategies for SAM training were evaluated, and the impact of prompt numbers and placements was assessed as well. The performance of the finalized workflow with optimized SAM was compared with five state-of-the-art (SOTA) models, and its robustness to prompt variations in middle-slice selection and box-prompt margins was analyzed.
resultsCompared to other fine-tuning methods, freezing the image encoder obtained the most stable performance. Prompts on only 3 slices achieved accuracy comparable to prompts on all slices. The placement of the middle-slice prompt exhibited negligible impact (p > 0.05). The finalized SAM-driven workflow outperformed end-to-end baseline models both visually and quantitatively (3D DSC: 0.92 vs 0.80; 3D HD95: 2.73 vs 12.70; IoU: 0.86 vs 0.67; Sensitivity: 91.20% vs 85.98%; Precision: 93.65% vs 79.23%), while maintaining stable performance across certain prompt variations.
conclusionsThe proposed SAM-driven interactive workflow with as few as 3 box prompts achieves favorable accuracy of GTV segmentation for rectal cancer neoadjuvant radiotherapy.
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