Evidence map›Paper›PMID 42905839›Full record

ArticleScience advances2026

The mRNA-based RSV vaccine mRNA-1345 induces robust and durable CD4

Anthony DiPiazza, Emily Marcisak, Wen-Han Yu, Daniel Makrinos, Hsiao-Hsuan Kuo, Jenna Landy, Shannon McGrath, Xiaolin Chang, Maria Cavallaro, Christopher Wu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Anthony DiPiazzaModerna Inc., Cambridge, MA, USA.ORCID 0000-0003-1989-8351
Emily MarcisakModerna Inc., Cambridge, MA, USA.ORCID 0000-0001-8624-1013
Wen-Han YuModerna Inc., Cambridge, MA, USA.ORCID 0000-0002-1671-9744
Daniel MakrinosModerna Inc., Cambridge, MA, USA.ORCID 0009-0006-1881-9913
Hsiao-Hsuan KuoModerna Inc., Cambridge, MA, USA.ORCID 0000-0003-3754-3271
Jenna LandyModerna Inc., Cambridge, MA, USA.ORCID 0000-0002-1411-8750
Shannon McGrathModerna Inc., Cambridge, MA, USA.ORCID 0009-0007-9943-6080
Xiaolin ChangModerna Inc., Cambridge, MA, USA.
Maria CavallaroModerna Inc., Cambridge, MA, USA.ORCID 0009-0004-5355-4450
Christopher WuModerna Inc., Cambridge, MA, USA.
Adam EsseneModerna Inc., Cambridge, MA, USA.
Haining LinModerna Inc., Cambridge, MA, USA.
Laura WalkerModerna Inc., Cambridge, MA, USA.ORCID 0000-0001-7704-3197
Andrea CarfiModerna Inc., Cambridge, MA, USA.ORCID 0000-0001-5508-3809
Jaap OostendorpModerna Inc., Cambridge, MA, USA.ORCID 0009-0000-9625-1979
Robert ParisModerna Inc., Cambridge, MA, USA.ORCID 0000-0003-3234-5989
Yanbo SunModerna Inc., Cambridge, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) remains a health threat, particularly for infants, older adults, and immunocompromised individuals. Although neutralizing antibodies can help limit infection and viral replication, T cells are essential for reducing disease severity. Assessment of age-related declines in T cell function are important for vaccine evaluation. We used intracellular cytokine staining, activation-induced marker, and Meso Scale Discovery assays and single-cell multiomic profiling to evaluate RSV vaccine mRNA-1345 responses in younger and older adults. mRNA-1345 induced comparable CD4

Indexed as

CD4-Positive T-LymphocytesRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus VaccinesRNA, MessengerAdultAgedCD8-Positive T-LymphocytesCytokinesFemaleHumansMaleMiddle AgedmRNA VaccinesYoung AdultCytokinesmRNA-1345 respiratory syncytial virus vaccinemRNA VaccinesRespiratory Syncytial Virus VaccinesRNA, Messenger

Identifiers

PMID42905839
PMCPMC13685949

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.