ArticleScience advances2026
In situ processing of fibrous hydrogels by photochemistry for adaptive cellular microenvironments.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Omnipresent in biology, fibrous networks like collagen possess unique properties: dynamic network via crosslinking and degradation. This intrinsic adaptivity plays a critical role in regulating cell behavior via cell-matrix interactions. Built from biological building blocks, however, these networks are challenging to manipulate or even control. Here, we introduce dynamic network regulation via photochemical control in a synthetic and fibrous highly biomimetic hydrogel. As a proof-of-concept, we demonstrate that the dynamic control over the mechanical properties of this adaptive in vitro model can be used to modulate cell spreading and mechanotransduction in three-dimensional (3D) mesenchymal stromal cell cultures. Our approach not only opens the door to on-demand mechanically adaptive gels with unprecedented control, but simultaneously offers easy processibility and cell extraction of the used synthetic gel.
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