Evidence map›Paper›PMID 42905754›Full record

ArticlePloS one2026

Predictors of preeclampsia with severe features: A multi-center analysis of maternal and health system factors in Thai tertiary hospitals.

Tippawan Boonyaporn, Piyanun Limruangrong, Ameporn Ratinthorn, Thitipong Tankumpuan

Abstract readMulticenter Study
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Tippawan BoonyapornDoctor of Nursing Science (Candidate), Faculty of Nursing, Mahidol University, Bangkok, Thailand.ORCID https://orcid.org/0009-0002-0551-9306
Piyanun LimruangrongDepartment of Obstetrics and Gynaecology Nursing, Faculty of Nursing, Mahidol University, Bangkok, Thailand.ORCID https://orcid.org/0009-0006-7081-9283
Ameporn RatinthornDepartment of Obstetrics and Gynaecology Nursing, Faculty of Nursing, Mahidol University, Bangkok, Thailand.
Thitipong TankumpuanDepartment of Surgical Nursing, Faculty of Nursing, Mahidol University, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreeclampsia (PE) with severe features threatens maternal and neonatal health. This study examined maternal and health-service factors associated with severe features and compared maternal and neonatal outcomes in Thailand.

methodsThis case-control study enrolled 156 postpartum women with PE (52 with and 104 without severe features) and 111 nurse-midwives in antenatal care, labor, and postpartum units across four Thai tertiary hospitals. Data were collected using postpartum and nurse-midwife questionnaires, and a maternal-neonatal health record form. Group differences were assessed using independent t-test, chi-square or Fisher's exact tests. Multivariable binary logistic regression examined factors associated with severe features, adjusting for antenatal care visits and gravidity.

resultsWomen with severe features more often had a history of PE (32.7% vs. 13.5%, p = 0.006) and differed in BMI distribution (p = 0.007). Three maternal factors were independently associated with severe features: history of PE (aOR = 5.99, 95% CI 2.13-16.83), BMI (aOR = 0.92 per kg/m2, 95% CI 0.86-0.98), and moderate versus low PE knowledge (aOR = 0.13, 95% CI 0.04-0.50). No health-service variable, including nurse training, was independently associated with severe features after adjustment (all p > 0.05). The model explained 29.4% (Nagelkerke R2) of the variance in PE severity and correctly classified 75.8% of cases. Infant birth weight was lower among women with severe features (p < 0.05); delivery mode, hospital stay, birth asphyxia, and NICU admission did not differ significantly.

conclusionA history of PE was associated with higher odds, and moderate (versus low) PE knowledge and higher BMI with lower odds, of severe features. These findings support prioritizing screening for prior PE history and structured antenatal knowledge counseling, together with adequately powered, multilevel studies to clarify the role of health-service factors in PE severity.

Indexed as

Pre-EclampsiaAdultCase-Control StudiesFemaleHumansInfant, NewbornPregnancyPrenatal CareRisk FactorsTertiary Care CentersThailand

Identifiers

PMID42905754
PMCPMC13686487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.