ReviewCell biochemistry and function2026
Reactive Oxygen Species as Central Coordinators of Organelle Stress and Tumor Radiosensitivity.
Guangyu Ju, Zimeng Wang, Jingjing Xiao, Qinxue Wu, Zhiying Yang, Yuqing Miao, Shuanghu Yuan, Junchao Qian
Abstract readReview
In one paragraphReview in Cell biochemistry and function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Guangyu JuDepartment of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P. R. China.ORCID https://orcid.org/0009-0001-6849-4372 Zimeng WangAnhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, P. R. China.
Jingjing XiaoAnhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, P. R. China.
Qinxue WuAnhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, P. R. China.
Zhiying YangAnhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, P. R. China.
Yuqing MiaoAnhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, P. R. China.
Shuanghu YuanDepartment of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P. R. China.ORCID https://orcid.org/0000-0002-8327-2524 Junchao QianDepartment of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P. R. China.ORCID https://orcid.org/0000-0003-0755-4885 Funding
Anhui Province Funds for Distinguished Young Scientists 2208085J10Key Science & Technology Project of Anhui Province 202523n10050005National Natural Science Foundation of China 81871085National Natural Science Foundation of China 82271519National Natural Science Foundation of China U1932158Natural Science Foundation of Shandong Province ZR2019LZL018Open Research Fund of State Key Laboratory of Digital Medical Engineering
6 · The paper itselfAbstract
Radiotherapy is a major modality for cancer treatment, but therapeutic responses vary substantially across tumor types and patients. Beyond direct DNA damage, radiation-induced reactive oxygen species (ROS) are increasingly recognized as dynamic regulators of cellular stress responses. Their biological effects depend not only on the magnitude of ROS generation, but also on its duration, subcellular distribution, and whether antioxidant, repair, and organelle quality-control systems can contain the resulting damage. Transient oxidative stress may activate adaptive responses, whereas persistent ROS can trigger mitochondrial ROS amplification, ER stress and Ca
Indexed as
NeoplasmsOrganellesOxidative StressRadiation ToleranceReactive Oxygen SpeciesAnimalsHumansReactive Oxygen Speciesorganelle crosstalkoxidative stressradio‐immunotherapyradiosensitivityradiotherapyreactive oxygen speciesredox homeostasistumor immunity
Identifiers
PMID42905732
PMCPMC13686383
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