Evidence map›Paper›PMID 42905731›Full record

ReviewCell biochemistry and function2026

Curcuminoids and Dimethoxycurcumin as Therapeutic Agents in Melanoma: Focus on Metastasis and Primary Care Integration.

Tivoli Visser, Charlise Basson, Priyesh Bipath, Yvette Nkondo Hlophe

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell biochemistry and function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tivoli VisserDepartment of Physiology, School of Medicine, University of Pretoria, Pretoria, South Africa.ORCID https://orcid.org/0009-0002-3294-8915
Charlise BassonDepartment of Physiology, School of Medicine, University of Pretoria, Pretoria, South Africa.ORCID https://orcid.org/0000-0002-6123-9707
Priyesh BipathDepartment of Physiology, School of Medicine, University of Pretoria, Pretoria, South Africa.
Yvette Nkondo HlopheDepartment of Physiology, School of Medicine, University of Pretoria, Pretoria, South Africa.ORCID https://orcid.org/0000-0002-3112-2436

Funding

National Research Foundation A1F685South African Medical Research Council A1H330
6 · The paper itself

Abstract

Melanoma is a type of skin cancer associated with the uncontrolled growth of melanocytes, the pigment-producing cells. This type of skin cancer continues to be a major concern owing to its strong tendency to spread. Melanoma progression is influenced by the activation of various signalling pathways, such as PI3K/AKT/mTOR, MAPK/ERK, and Wnt/β-catenin pathways. Curcuminoids, derived from turmeric, are known for their anti-inflammatory and antioxidant properties and influence the PI3K/AKT/mTOR pathway by acting on key molecules, such as mTORC1, PI3K, and AKT. Curcuminoids have demonstrated reduced ERK phosphorylation, which lowers MAPK pathway activity. Additionally, curcuminoids have been shown to block the cell cycle at the G

Indexed as

Antineoplastic AgentsCurcuminDiarylheptanoidsMelanomaSkin NeoplasmsAnimalsHumansNeoplasm MetastasisSignal TransductionAntineoplastic AgentsCurcuminDiarylheptanoidscurcuminoidsdimethoxycurcuminMAPK/ERKMelanomaPI3K/AKT/mTORturmeric

Identifiers

PMID42905731
PMCPMC13686273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.