ArticleArchives of endocrinology and metabolism2026
Thymic hyperplasia in patients with acromegaly: imaging-based assessment and clinical implications.
Article in Archives of endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to compare thymus visibility and volume in patients with acromegaly to those of controls, and to evaluate the correlation between growth hormone (GH), insulin-like growth factor-1 (IGF-1) levels, and thymus volume. SUBJECTS AND
methodsThis cross-sectional case-control study included 66 patients with acromegaly who underwent thoracic computed tomography scans. An age- and sex-matched control group of 65 trauma patients without comorbidities was selected. All thoracic computed tomography scans were reassessed to measure thymus volume using imaging software. Comparisons of thymus volume and assessment of correlation with GH and IGF-1 levels were performed.
resultsThe acromegaly group (28F/38M) and the control group (27F/38M) had similar sex and age distributions. The thymus was more frequently detectable in the acromegaly group (80.3%) compared to controls (44.6%; p = 0.001). Thymus volume was significantly higher in the acromegaly group (13.1 cm3 [9.7-18.7]) than in the control (10.3 cm3 [4.6-12.3]; p = 0.013). Serum IGF-1 levels were nearly significantly higher in acromegalic patients with a visible thymus compared to those without (visible thymus: 608.5 ng/mL [377.6-921.8]; non-visible thymus: 440.5 ng/mL [201.5-596]; p = 0.054). However, no significant differences were found in GH and IGF-1 upper limit of normal levels. No correlation was found between thymus volume and other parameters.
conclusionPatients with acromegaly have larger and more frequently visible thymus glands than controls. When a mass is detected in the anterior mediastinum, acromegaly should be considered, especially before invasive procedures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.