Evidence map›Paper›PMID 42905449›Full record

ArticleeLife2026

p66Shc mediates SUMO2-induced endothelial dysfunction.

Jitendra Kumar, Shravan K Uppulapu, Sujata Kumari, Kanika Sharma, William J Paradee, Ravi Prakash Yadav, Vikas Kumar, Santosh Kumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jitendra KumarDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Iowa City, United States.ORCID https://orcid.org/0000-0003-4222-446X
Shravan K UppulapuDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Iowa City, United States.ORCID https://orcid.org/0000-0001-5591-8167
Sujata KumariDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Iowa City, United States.ORCID https://orcid.org/0009-0006-7344-7227
Kanika SharmaDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, United States.ORCID https://orcid.org/0009-0002-8754-9655
William J ParadeeGenome Editing Core Facility, University of Iowa, Iowa City, United States.
Ravi Prakash YadavRegional Institute of Education-NCERT, Mysore, India.ORCID https://orcid.org/0000-0002-6243-8388
Vikas KumarDepartment of Biochemistry and Molecular Biotechnology, Mass Spectrometry Facility, University of Massachusetts Chan Medical School, Worcester, United States.
Santosh KumarDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Iowa City, United States.ORCID https://orcid.org/0000-0003-1418-2020

Funding

SUMO2-p66shc axis in vascular endothelial dysfunction and atherosclerosisR01HL152132 · NHLBI · UNIVERSITY OF IOWA · PI KUMAR, SANTOSH · 2020 to 2024
$2.1M
CFTR and Vascular endothelial functionR21AG086743 · NIA · UNIVERSITY OF IOWA · PI KUMAR, SANTOSH · 2025 to 2025
$428k
Cystic Fibrosis Foundation 005803I223NHLBI NIH HHS R01HL152132NIA NIH HHS R21AG086743
6 · The paper itself

Abstract

Sumoylation is a post-translational modification that can regulate different physiological functions. Increased sumoylation, specifically conjugation of SUMO2/3 (small ubiquitin-like modifier 2/3), is detrimental to vascular health. However, the molecular mechanism mediating this effect is poorly understood. We used cell-based assays and mass spectrometry to show that p66Shc is a direct target of SUMO2 and that SUMO2 regulates p66Shc function via lysine-81 modification. To determine the effects of SUMO2-p66ShcK81 on vascular function, we generated Shc1

Indexed as

Endothelial CellsSmall Ubiquitin-Related Modifier ProteinsSrc Homology 2 Domain-Containing, Transforming Protein 1AnimalsHumansHyperlipidemiasMass SpectrometryMiceMice, KnockoutSignal TransductionSumoylationShc1 protein, mouseSmall Ubiquitin-Related Modifier ProteinsSrc Homology 2 Domain-Containing, Transforming Protein 1SUMO2 protein, mousecell biologyendothelial functionhumanmousep66Shcsumoylation

Identifiers

PMID42905449
PMCPMC13686634

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.