Evidence map›Paper›PMID 42905335›Full record

ArticleProbiotics and antimicrobial proteins2026

Comparative Effects of Lacticaseibacillus rhamnosus and Lactobacillus delbrueckii on the Proliferative, Anti-apoptotic, and Tolerogenic Properties of Adipose-Derived Mesenchymal Stem Cells.

Sahar Khorasani, Fatemeh Faraji, Atefeh Alaei, Mohammadali Nahayati, Nafiseh Sadat Tabasi, Nazanin Forghani, Fahimeh Lavi Arab, Mahmoud Mahmoudi

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Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sahar KhorasaniImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Fatemeh FarajiImmunology Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
Atefeh AlaeiImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammadali NahayatiDepartment of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Nafiseh Sadat TabasiImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Nazanin ForghaniStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Fahimeh Lavi Arab *Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Fahime.lavi@gmail.com.
Mahmoud Mahmoudi *Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. MahmoudiM@mums.ac.ir.

Funding

Mashhad University of Medical Sciences 4011415
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are promising therapeutic candidates for multiple sclerosis (MS). Probiotics also exhibit anti-inflammatory effects, and tolerogenic stains may help modulate immune responses in autoimmune diseases. This study evaluated the effects of Lacticaseibacillus rhamnosus (formerly Lactobacillus rhamnosus) and Lactobacillus delbrucekii on the immunomodulatory properties and cytokine-expression profile of adipose-derived MSCs (AD-MSCs) isolated from patients with MS. AD-MSCs were isolated and characterized, then treated separately or in combination with different concentrations of L. rhamnosus and L. delbrucekii. Cell proliferation and apoptosis were assessed by MTT assay and flow cytometery, respectively. Following 24 h of co-culture of AD-MSCs with peripheral blood mononuclear cells (PBMCs) from healthy donors in the presence of probiotic candidate strains, the frequency of regulatory T cells (Tregs) and expression of IL1, IL6, IL17, FOXP3, TGFβ, and IL4 were evaluated by flow cytometery and real-time PCR, respectively. Both probiotic candidate strains, particularly at 10

Indexed as

Adipose tissueImmunomodulationLactobacillus delbrueckiiLactobacillus rhamnosusMesenchymal stem cellsProbioticsTreg cells

Identifiers

PMID42905335

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.